Evaluation of androgenic status in patients with primary hypothyroidism
Background. Role of androgenic deficiency in men as a factor of disease pathogenesis is beyond doubt. Interaction of thyroid and sexual hormones in men with hypothyroidism remains controversial. The purpose was to evaluate androgenic status in men with primary hypothyroidism depending on its duration and state of compensation. Materials and methods. We have examined 45 male patients with primary hypothyroidism aged 35 to 60 years. Enrollment of men was conducted during outpatient visits and in-patient treatment in the endocrinology department of the Ternopil University hospital. Results. Decreased level of total testosterone (tТ) was detected in 42.2 % of patients with hypothyroidism. Thus, in 17.8 % of patients, tТ blood level was below 8.0 nM/l, and in 11 (24.4 %) men, this index was between 8.0 and 12.0 nM/l. According to the results of evaluating the content of free testosterone, the incidence of laboratory hypogonadism in men with hypothyroidism appeared to be higher than when determining tТ. The degree of hypothyroidism compensation did not influence significantly the average levels of gonadotropic and sexual hormones. Conclusions. Levels of sex hormone-binding globulin were significantly decreased in 46.7 % of patients with hypothyroidism as compared to the control group. The average levels of estradiol in the examined patients did not differ significantly from the average indexes in men from the control group. The obtained data may indicate a combined lesion of the central and peripheral links of the pituitary-gonadal system in men with hypothyroidism.
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Carani C, Isodori A, Granata A. Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J Clin Endocrinol Metab. 2005 Dec;90(12):6472-9. doi: 10.1210/jc.2005-1135.
Nieschlag E, Swerdloff R, Behre HM, et al. Investigation, treatment and monitoring international of late-onset hypogonadism in males: ISA, ISSAM, EAU recommendations. Int J Androl. 2005 Jun;28(3):125-127. doi: 10.1111/j.1365-2605.2005.00553.x.
Wang C, Nieschlag E, Swerdloff R, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur Urol. 2009 Jan;55(1):121-30. doi: 10.1016/j.eururo.2008.08.033.
Kapoor D, Aldred H, Clark S, Channer KS, Jones TH. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: сorrelations with bioavailable testosterone and visceral adiposity. Diabetes Care. 2007;30(4):911-917. doi: 10.2337/dc06-1426.
Corona J, Mannucci E, Petrone L, et al. NCEP-ATPIII – defined metabolic syndrome, type 2 diabetes mellitus, and prevalence of hypogonadism in male patients with sexual dysfunction. J Sex Med. 2007 Jul;4(4 Pt 1):1038-1045. doi: 10.1111/j.1743-6109.2007.00529.x.
Krassas GE, Papadopoulou F, Tziomalos K, Zeginiadou T, Pontikides N. Hypothyroidism has an adverse effect on human spermatogenesis: A prospective, controlled study. Thyroid. 2008 Dec;18(12):1255-9. doi: 10.1089/thy.2008.0257.
Osuna JA, Gómez-Pérez R, Arata-Bellabarba G, Villaroel V. Relationship between BMI, total testosterone, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men. Arch Androl. 2006;52(5):355-61. doi: 10.1080/01485010600692017.
Laaksonen DE, Niskanen L, Punnonen K, et al. The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study. J Clin Endocrinol Metab. 2005 Feb;90(2):712-9. doi: 10.1210/jc.2004-0970.
Simon D, Charles MA, Nahoul K, et al. Association between plasma levels total testosterone and cardiovascular risk factors in healthy adult men: The Telecom Study. J Clin Endocrinol Metab. 1997 Feb;82(2):682-5. doi: 10.1210/jcem.82.2.3766.
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