Features of carbohydrate metabolism in women of early reproductive age with polycystic ovary syndrome

Main Article Content

L.M. Semeniuk
T.Yu. Yuzvenko
O.V. Larina


Background. Fertility of women, especially with an endocrine hyperandrogenic imbalance, requires special attention, as incidence of reproductive losses in this group reaches almost 67 %. The objective is to determine the correlation between body mass index, violations of carbohydrate metabolism and vitamin D level in clinical symptoms of polycystic ovary syndrome (PCOS). Materials and me­thods. Hormonal analysis is conducted during days 5–7 of menstrual cycle by evaluating serum levels of follicle-stimu­lating and luteinizing hormones, testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, dehydrotestosterone in 45 women with PCOS aged 18–25 years. Results. The relationship between vitamin D content and hormonal maintenance of the reproductive system in women with PCOS has been traced; a trigger role of redu­cing the level of vitamin D has been shown in the formation of hormonal imbalance and clinical hyperandrogenic manifestations of insulin resistance in women with PCOS. Conclusions. Patients with PCOS and insufficient level of vitamin D, despite the absence of excessive body weight and obesity, have more significant changes in carbohydrate metabolism than patients without PCOS.

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How to Cite
Semeniuk, L., T. Yuzvenko, and O. Larina. “Features of Carbohydrate Metabolism in Women of Early Reproductive Age With Polycystic Ovary Syndrome”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 14, no. 3, Apr. 2018, pp. 229-34, doi:10.22141/2224-0721.14.3.2018.136417.
Original Researches


Sharma R, Biedenharn KR, Fedor JM, Agarwal A. Lifestyle factors and reproductive health: taking control of your fertility. Reprod Biol Endocrinol. 2013 Jul 16;11:66. doi: 10.1186/1477-7827-11-66.

Semenyuk LM, Yarotsky ME, Likhachov VK, Dobrovolska LM. Changes in hormonal and immunological regulation as a predictor of miscarriage in women with hyperandrogenism. Visnyk problem biologii i medytsyny. 2015;4(1):135-138. (in Ukrainian).

Celik C, Tasdemir N, Abali R, Bastu E, Yilmaz M. Progression to impaired glucose tolerance or type 2 diabetes mellitus in polycystic ovary syndrome: a controlled follow-up study. Fertil Steril. 2014 Apr;101(4):1123-8.e1. doi: 10.1016/j.fertnstert.2013.12.050.

Morley LC, Tang T, Yasmin E, Norman RJ, Balen AH. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev. 2017 Nov 29;11:CD003053. doi: 10.1002/14651858.CD003053.pub6.

He C, Lin Z, Robb SW, Ezeamama AE. Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients. 2015 Jun 8;7(6):4555-77. doi: 10.3390/nu7064555.

Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012 Sep;77(3):343-50. doi: 10.1111/j.1365-2265.2012.04434.x.

Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.

Wild RA1, Rizzo M, Clifton S, Carmina E. Lipid levels in polycystic ovary syndrome: Systematic review and meta-analysis. Fertil Steril. 2011 Mar 1;95(3):1073-9.e1-11. doi: 10.1016/j.fertnstert.2010.12.027.

Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012 Sep;77(3):343-50. doi: 10.1111/j.1365-2265.2012.04434.x.

de Groot PC, Dekkers OM, Romijn JA, Dieben SW, Helmerhorst FM. PCOS, coronary heart disease, stroke and the influence of obesity: A systematic review and meta-analysis. Hum Reprod Update. 2011 Jul-Aug;17(4):495-500. doi: 10.1093/humupd/dmr001.

Khan H, Kunutsor S, Franco OH, Chowdhury R. Vitamin D, type 2 diabetes and other metabolic outcomes: A systematic review and meta-analysis of prospective studies. Proc Nutr Soc. 2013 Feb;72(1):89-97. doi: 10.1017/S0029665112002765.

Song Y, Wang L, Pittas AG, et al. Blood 25-hydroxyvitamin D levels and incident type 2 diabetes: A meta-analysis of prospective studies. Diabetes Care. 2013 May;36(5):1422-8. doi: 10.2337/dc12-0962.

Verdoia M, Schaffer A, Sartori C, et al. Vitamin D deficiency is independently associated with the extent of coronary artery disease. Eur J Clin Invest. 2014 Jul;44(7):634-42. doi: 10.1111/eci.12281.

Krul-Poel YH, Snackey C, Louwers Y, et al. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: A systematic review. Eur J Endocrinol. 2013 Oct 23;169(6):853-65. doi: 10.1530/EJE-13-0617.

Wehr E, Pilz S, Schweighofer N, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol. 2009 Oct;161(4):575-82. doi: 10.1530/EJE-09-0432.

Hassan NE, El-Orabi HA, Eid YM, Mohammed NR. Effect of 25-hydroxyvitamin D on metabolic parameters and insulin resistance in patients with polycystic ovarian syndrome. Middle East Fertil Soc J. 2012;17(3):176-180. doi: 10.1016/j.mefs.2012.04.005.

Nestler JE, Reilly ER, Cheang KI, Bachmann LM, Downs RW Jr. A pilot study: Effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. Trans Am Clin Climatol Assoc. 2012;123:209-19; discussion 219-20.

Li HW, Brereton RE, Anderson RA, Wallace AM, Ho CK.Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism. 2011 Oct;60(10):1475-81. doi: 10.1016/j.metabol.2011.03.002.

Tsakova AD, Gateva AT, Kamenov ZA. 25(OH) vitamin D levels in premenopausal women with polycystic ovary syndrome and/or obesity. Int J Vitam Nutr Res. 2012 Dec;82(6):399-404. doi: 10.1024/0300-9831/a000137.

Güdücü N, Görmüş U, Kutay SS, Kavak ZN, Dünder I. 25-hydroxyvitamin D levels are related to hyperinsulinemia in polycystic ovary syndrome. Gynecol Endocrinol. 2014 Aug;30(8):557-60. doi: 10.3109/09513590.2014.910189.

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