Pituitary Cushing’s syndrome: analysis of the newly diagnosed cases

M.L. Kyryliuk, T.I. Dashuk, N.V. Kyryliuk


A description of 4 cases of newly diagnosed Cu­shing’s pituitary syndrome (PCS) is presented. The feature of the first case of PCS is the manifestation of the disease in the form of 2 spontaneous fractures of the foot bones, the absence of classical striae on the trunk and hips, low potassium, normoglycemia, preserved circadian rhythm of cortisol secretion. In the second case of PCS, the first manifestation of the disease is compression fracture of the spine, normoglycemia, preserved circadian rhythm of cortisol secretion, significant adrenal hyperandroge­nism, secondary hyperparathyroidism and vitamin D3-deficiency state, absence of eosinophils in peripheral blood. In the third case of PCS — the early onset (presumably at age 16), absence of compression fractures in the past medical history, clinically significant menstrual disorders, low potassium, disorders of the mineral and carbohydrate metabolism. In the fourth case of PCS — diabetes mellitus, absence of fractures in the past medical history and classical striae on the skin of the trunk and hips.


pituitary Cushing’s syndrome

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