Features of the nervous system lesion in primary hypothyroidism (literature review)

I.I. Bilous, L.B. Pavlovych

Abstract


The review presents the pathogenetic mechanisms of central and peripheral nervous system pathology in primary hypothyroidism. Lack of thyroid hormones leads to changes in the organization of the central nervous system, decrease in the energy supply of neurons, changes in the synthesis of some specific proteins of the nervous system that cause the development of cretinism in children. The role of hypothyroidism in the development of cognitive impairment in adults, such as decreased cognitive function, memory and attention, has been proved. The impairment of logical thinking is found already in patients with subclinical hypothyroidism. Disorders in mediation exchange lead to the development of depression. Neuromuscular disorders (hypothyroid myopathy and myotonic phenomenon) and affection to the peripheral nerves are best studied in hypothyroidism. Primary hypothyroidism may be masked by tunnel neuropathy, polyneuropathy and atactic syndrome. Despite the existing papers on the problem of hypothyroidism and its neurological complications, some issues of pathogenesis, diagnosis, course and treatment of neurological pathology in primary hypothyroidism require further research.

Keywords


hypothyroidism; subclinical hypothyroidism; nervous system; review

References


Thvilum M, Brandt F, Almind D, Christensen K, Brix TH, Hegedüs L. Increased psychiatric morbidity before and after the diagnosis of hypothyroidism: a nationwide register study. Thyroid. 2014 May;24(5):802-8. doi: 10.1089/thy.2013.0555.

Pashkovska NV. Treatment of hypothyroidism according to modern clinical guidelines. Mìžnarodnij endokrinologìčnij žurnal. 2016;(78):48-58. doi: 10.22141/2224-0721.6.78.2016.81860. (in Ukrainian).

Bathla M, Singh M, Relan P. Prevalence of anxiety and depressive symptoms among patients with hypothyroidism. Indian J Endocrinol Metab. 2016 Jul-Aug;20(4):468-74. doi: 10.4103/2230-8210.183476.

Quinque EM, Karger S, Arélin K, Schroeter ML, Kratzsch J, Villringer A. Structural and functional MRI study of the brain, cognition and moodin long-term adequately treated Hashimoto’s thyroiditis. Psychoneuroendocrinology. 2014 Apr;42:188-98. doi: 10.1016/j.psyneuen.2014.01.015.

Mahadule AA, Jadhao PS, Phatak MS. Motor conduction parameters in recently diagnosed and untreated hypothyroidism. Ann Neurosci. 2015 Jan;22(1):6-10. doi: 10.5214/ans.0972.7531.220103.

Saltevo J, Kautiainen H, Mäntyselkä P, et al. The relationship between thyroid function and depressive symptoms-the FIN-D2D population-based study. Clin Med Insights Endocrinol Diabetes. 2015 Apr 20;8:29-33. doi: 10.4137/CMED.S24111.

Dayan CM, Panicker V. Hypothyroidism and depression. Eur Thyroid J. 2013 Sep;2(3):168-79. doi: 10.1159/000353777.

Hage MP, Azar ST. The Link between Thyroid Function and Depression. J Thyroid Res. 2012;2012:590648. doi: 10.1155/2012/590648.

Kalra S, Balhara YP. Euthyroid depression: The role of thyroid hormone. Recent Pat Endocr Metab Immune Drug Discov. 2014 Jan;8(1):38-41. PMID: 24372347.

Zaletel K, Gaberšček S. Hashimoto's thyroiditis: from genes to the disease. Curr Genomics. 2011 Dec;12(8):576-88. doi: 10.2174/138920211798120763.

Staii A, Mirocha S, Todorova-Koteva K, Glinberg S, Jaume JC. Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state. Thyroid Res. 2010;3:11-18. PMID: 21172028.

Blum MR, Wijsman LW, Virgini VS, et al. Subclinical thyroid dysfunction and depressive symptoms among elderly: a prospective cohort study. Neuroendocrinology. 2016;103(3-4):291-9. doi: 10.1159/000437387.

Wu EL, Chien IC, Lin CH, Chou YJ, Chou P. Increased risk of hypothyroidism and hyperthyroidism in patients with major depressive disorder: a population-based study. J Psychosom Res. 2013 Mar;74(3):233-7. doi: 10.1016/j.jpsychores.2012.12.016.

Ferretti E, Tosi E, Po A, et al. Notch signaling is involved in expression of thyrocyte differentiation markers and is down-regulated in thyroid tumors. J Clin Endocrinol Metab. 2008 Oct;93(10):4080-7. doi: 10.1210/jc.2008-0528.

Sharma V, Borah P, Basumatary LJ, Das M, Goswami M, Kayal AK. Myopathies of endocrine disorders: a prospective clinical and biochemical study. Ann Indian Acad Neurol. 2014 Jul;17(3):298-302. doi: 10.4103/0972-2327.138505.

El-Salem K, Ammani F. Neurophysiological changes in neurologically asymptomatic hypothyroid patients: a prospective cohort study. J Clin Neurophysiol. 2006 Dec;23(6):568-72. doi: 10.1097/01.wnp.0000231273.22681.0e.

Radhakrishnan R, Calvin S, Singh JK, Thomas B, Srinivasan K. Thyroid dysfunction in major psychiatric disorders in a hospital based sample. Indian J Med Res. 2013 Dec;138(6):888-93. PMID: 24521631.

Kilby MD, Gittoes N, McCabe C, Verhaeg J, Franklyn JA. Expression of thyroid receptor isoforms in the human fetal central nervous system and the effects of intrauterine growth restriction. Clin Endocrinol (Oxf). 2000 Oct;53(4):469-77. PMID: 11012572.

Medici M, Direk N, Visser E, et al. Thyroid function within the normal range and the risk of depression: a population-based cohort study. J Clin Endocrinol Metab. 2014 Apr;99(4):1213-9. doi: 10.1210/jc.2013-3589.

Giynas Ayhan M, Uguz F, Askin R, Gonen MS. The prevalence of depression and anxiety disorders in patients with euthyroid Hashimoto's thyroiditis: a comparative study. Gen Hosp Psychiatry. 2014 Jan-Feb;36(1):95-8. doi: 10.1016/j.genhosppsych.2013.10.002.

Sparling DP, Fabian K, Harik L, et al. Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase. J Pediatr Endocrinol Metab. 2016 May 1;29(5):627-31. doi: 10.1515/jpem-2015-0253.

Lobasso A, Nappi L, Barbieri L, et al. Severe Hypothyroidism due to the Loss of Therapeutic Efficacy of l-Thyroxine in a Patient with Esophageal Complication Associated with Systemic Sclerosis. Front Endocrinol (Lausanne). 2017 Sep 20;8:241. doi: 10.3389/fendo.2017.00241.

Ittermann T, Volzke H, Baumeister SE, Appel K, Grabe HJ. Diagnosed thyroid disorders are associated with depression and anxiety. Soc Psychiatry Psychiatr Epidemiol. 2015 Sep;50(9):1417-25. doi: 10.1007/s00127-015-1043-0.

Pelúcio L, Nardi AE, Ornelas AC, Levitan M. Psychiatric Disorders and Quality of Life in Patients with Hypothyroidism: A Narrative Review. J Depress Anxiety. 2016;(5):241. doi: 10.4200/2167- 1044.1000241.

Stamm TJ, Lewitzka U, Sauer C, et al. Supraphysiologic doses of levothyroxine as adjunctive therapy in bipolar depression: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2014 Feb;75(2):162-8. doi: 10.4088/JCP.12m08305.

Menon V, Subramanian K, Thamizh JS. Psychiatric Presentations Heralding Hashimoto's Encephalopathy: A Systematic Review and Analysis of Cases Reported in Literature. J Neurosci Rural Pract. 2017 Apr-Jun;8(2):261-267. doi: 10.4103/jnrp.jnrp_440_16.

Cosci F, Fava GA, Sonino N. Mood and anxiety disorders as early manifestations of medical illness: a systematic review. Psychother Psychosom. 2015;84(1):22-9. doi: 10.1159/000367913.

Kirim S, Keskek SO, Köksal F, Haydardedeoglu FE, Bozkirli E, Toledano Y. Depression in patients with euthyroid chronic autoimmune thyroiditis. Endocr J. 2012;59(8):705-8. PMID: 22673294.

Brown BT, Graham PL, Bonello R, Pollard H. A biopsychosocial approach to primary hypothyroidism: Treatment and harms data from a randomized controlled trial. Chiropr Man Therap. 2015 Aug 20;23:24. doi: 10.1186/s12998-015-0068-5.




DOI: https://doi.org/10.22141/2224-0721.14.2.2018.130563

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