Vitamin-mineral premix and treatment of diffusive nontoxic goiter
Background. The content of microelements and vitamins was studied in adolescents with diffuse nontoxic goiter (DNG). The purpose of the study is to substantiate the use of vitamin-mineral premixes in the treatment of adolescents with DNG. Materials and methods. In 109 girls and 97 boys aged 9–17 years with DNG, the content of vitamins (A, E, B1 and B2), essential (Se, Zn) and toxic (Pb, Cd, Co) trace elements was evaluated taking into account the functional state of the thyroid system and the goiter course. Results. The degree of vitamin and microelement imbalance influences the formation and course of DNG. It was found that the unfavorable course of DNG occurs against the background of a significant decrease in the content of vitamin A, Se and Zn and excessive accumulation of Pb and Cd. The nature of the relationship between the functional state of the thyroid system, the content of vitamins and microelements were studied in patients with DNG. It is proved that treatment and secondary prevention of DNG involves not only the use of potassium iodide preparations, but also correction of vitamin-mineral imbalance with additional prescription of Se, Zn, group A, E and B vitamins. Conclusions. Imbalance of vitamins and microelements is an additional factor in the formation of DNG in conditions of mild iodine deficiency. The unfavorable course of DNG occurs against the background of a decrease in the level of vitamin A, essential trace elements (Se and Zn) and excessive accumulation of toxic trace elements (Pb and Cd). Correction of vitamin-mineral imbalance is a necessary component of the treatment for DNG and prevention of its unfavorable course. In case of a decrease in the Se level, it is advisable to use the antioxidant complex OxyLyc, and in case of zinc deficiency, Zinkit is prescribed additionally.
Full Text:PDF (Українська)
Veldanova MV. Endemic goitre as microelementosis. Meditsinskii nauchnyi i uchebno-metodicheskii zhurnal. 2001;(6):150-173. (in Russian).
Ertek S, Cicero AF, Caglar O, Erdogan G. Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation. Hormones (Athens). 2010 Jul-Sep;9(3):263-8. PMID: 20688624.
Triggiani V, Tafaro E, Giagulli VA, et al. Role of iodine, selenium and other micronutrients in thyroid function and disorders. Endocr Metab Immune Disord Drug Targets. 2009 Sep;9(3):277-94. PMID: 19594417.
Pankiv VI. Problem of combined selenium and iodine deficiency in the development of thyroid pathology. Mìžnarodnij endokrinologìčnij žurnal. 2014;(61):75-80. doi: 10.22141/2224-07126.96.36.1994.76859. (in Russian).
Aydin K, Kendirci M, Kurtoğlu S, Karaküçük EI, Kiriş A. Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. J Pediatr Endocrinol Metab. 2002 Jul-Aug;15(7):1027-31. PMID: 12199330.
Combs GF, Midthune DN, Patterson KY, et al. Effects of selenomethionine supplementation on selenium status and thyroid hormone concentration in healthy adults. Am J Clin Nutr. 2009 Jun;89(6):1808-14. doi: 10.3945/ajcn.2008.27356.
Goncharova OA. Justification for identifying selenodefitsitnyh areas in Ukraine and organizations corrective measures (literature review and own data). Problemi endokrinnoi patologii. 2016;1(55):63-70. (in Russian).
Osadtsiv OI, Vasilkova GM, Kravchenko VI, Andrusishina IM, Ulanovich TV, Osadtsiv IV. Research of environment trace elements influence on diffuse goiter development at children of the Chernigov region. Endokrynologia. 2012;17(2):7-15. (in Ukrainian).
Karachentsev YuI, Goncharova OA, Podoroga YeI, Ilyina IM, Nikishina LE. Selenium supply of certain areas of Sumy region and features of thyroid pathology prevalence. Mìžnarodnij endokrinologìčnij žurnal. 2013;(53):17-20. doi: 10.22141/2224-07188.8.131.523.84474. (in Russian).
Barysheva ES. The role of microelements in the functional and structural homoeostasis of the thyroid gland (clinical and experimental research). Mìžnarodnij endokrinologìčnij žurnal. 2010;(31):15-25. (in Russian).
Hess SY. The impact of common micronutrient deficiencies on iodine and thyroid metabolism: the evidence from human studies. Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):117-32. doi: 10.1016/j.beem.2009.08.012.
Aminzadeh M, Karamizadeh Z, Amirhakimi GH, Zare-Javid A. Is there a Difference in Zinc and Vitamin A Status between Children with and without Goiter. J Food Nutr Disor. 2013;2:5. doi:10.4172/2324-9323.1000127.
Lippi G, Montagnana M, Targher G, Salvagno GL, Guidi GC. Prevalence of folic Acid and vitamin B12 deficiencies in patients with thyroid disorders. Am J Med Sci. 2008 Jul;336(1):50-2. doi: 10.1097/MAJ.0b013e31815c3b5b.
Muhlbauer M, da Silva AC, Marassi MP, Lourenço AL, Ferreira AC, de Carvalho DP. Retinoic acid modulation of thyroid dual oxidase activity in rats and its impact on thyroid iodine organification. J Endocrinol. 2010 Jun;205(3):271-7. doi: 10.1677/JOE-09-0421.
Silva AC, Marassi MP, Muhlbauer M, Lourenço AL, Carvalho DP, Ferreira AC. Retinoic acid effects on thyroid function of female rats. Life Sci. 2009 May 8;84(19-20):673-7. doi: 10.1016/j.lfs.2009.02.010.
Biebinger R, Arnold M, Langhans W, Hurrell RF, Zimmermann MB. Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size. J Nutr. 2007 Mar;137(3):573-7. PMID: 17311942.
Koh M, Takitani K, Miyazaki H, Yamaoka S, Tamai H. Liver X receptor up-regulates α-tocopherol transfer protein expression and α-tocopherol status. J Nutr Biochem. 2013 Dec;24(12):2158-67. doi: 10.1016/j.jnutbio.2013.08.008.
Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE. Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands. J Biol Chem. 2009 Jul 17;284(29):19659-67. doi: 10.1074/jbc.M109.013458.
Jindahra P, Dejthevaporn C, Komindr S, Songchitsomboon S, Witoonpanich R. Polyneuropathy from thiamin deficiency associated with thyrotoxicosis. J Med Assoc Thai. 2005 Oct;88(10):1438-41. PMID: 16519393.
Turan M, Cayir A, Cetin N, et al. An investigation of the effect of thiamine pyrophosphate on cisplatin-induced oxidative stress and DNA damage in rat brain tissue compared with thiamine: thiamine and thiamine pyrophosphate effects on cisplatin neurotoxicity. Hum Exp Toxicol. 2014 Jan;33(1):14-21. doi: 10.1177/0960327113485251.
Torshin IY, Gromova OA, authors; Skvortcova VI, Suhih GT, editors. Magnesium and pyridoxine: fundamental studies and clinical practice. New York: Nova Science Publishers; 2009. 250 p.
Ministry of Нealth of Ukraine. Order № 254 dated April 27, 2006. On the approval of protocols for the provision of medical assistance to children in the specialty "Pediatric Endocrinology". Available from: http://old.moz.gov.ua/ua/portal/dn_20060427_254.html. Accessed: April 27, 2006. (in Ukrainian).
Samsonov MA. Conception of the balanced nutrition and its value in the study of mechanisms of curative food action. Voprosy pitaniia. 2001;5:3-9. (in Russian).
Shchepliagina LA, Makulova ND, Maslova OI. State of cognitive sphere in children from districts with the iodine deficiency. Rossiiskii Pediatricheskii Zhurnal. 2007;(2):29-41. (in Russian).
Kamins'kyj OV , Afanas'jev DJe , Kovalenko OM, Tepla OV , Cheren'ko SM, authors; Kamins'kyj OV, editor. Standarty nadannja medychnoi' dopomogy hvorym z patologichnymy stanamy shhytopodibnoi' zalozy v umovah dii' negatyvnyh chynnykiv dovkillja: metodychnyj posibnyk [Standards for the provision of medical care to patients with pathological conditions of the thyroid gland under conditions of exposure to negative environmental factors: a methodical manual]. 2nd ed. Kyiv: Start-98; 2015. 224 p. (in Ukrainian).
Alekseev VV, Alipov AN, Andreev VA, et al, authors; Karpishchenko AI, editor. Meditsinskie laboratornye tekhnologii: rukovodstvo po klinicheskoi laboratornoi diagnostike. Tom 2 [Medical laboratory technologies: manual for clinical laboratory diagnostics. Vol. 2]. 3d ed. Мoscow: GEOTAR-Media; 2013. 792 p. (in Russian).
Nasledov A. SPSS 19: Professional'nyi statisticheskii analiz dannykh [SPSS 19: Professional statistical analysis of data]. SPb: Piter; 2008. 416 p. (in Russian).
Moskva KhA, Kikhtiak OP, Makar RD. Influence of the fixed combination of iodine and selenium on the course of autoimmune thyroiditis in iodine deficiency region. Mìžnarodnij endokrinologìčnij žurnal. 2014;(64):38-42. doi: 10.22141/2224-07184.108.40.2064.77861. (in Ukrainian).
Muratova ShT, Ismailov SI. Influence of Graves’ disease on psychocognitive state of children and adults (literature review). Mìžnarodnij endokrinologìčnij žurnal. 2015;(70):86-89. doi:10.22141/2224-07220.127.116.115.72645. (in Russian).
Troshina YeA, Platonova NM, Soloviyeva SI, Abdulkhabirova FM. Intellectual development of the school students with diffusive clinically euthyroid goiter in the regions with different iodine occurrence. Pediatricheskaya Farmakologiya. 2009;6(2):43-48. (in Russian).
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2019