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Background. The content of microelements and vitamins was studied in adolescents with diffuse nontoxic goiter (DNG). The purpose of the study is to substantiate the use of vitamin-mineral premixes in the treatment of adolescents with DNG. Materials and methods. In 109 girls and 97 boys aged 9–17 years with DNG, the content of vitamins (A, E, B1 and B2), essential (Se, Zn) and toxic (Pb, Cd, Co) trace elements was evaluated taking into account the functional state of the thyroid system and the goiter course. Results. The degree of vitamin and microelement imbalance influences the formation and course of DNG. It was found that the unfavorable course of DNG occurs against the background of a significant decrease in the content of vitamin A, Se and Zn and excessive accumulation of Pb and Cd. The nature of the relationship between the functional state of the thyroid system, the content of vitamins and microelements were studied in patients with DNG. It is proved that treatment and secondary prevention of DNG involves not only the use of potassium iodide preparations, but also correction of vitamin-mineral imbalance with additional prescription of Se, Zn, group A, E and B vitamins. Conclusions. Imbalance of vitamins and microelements is an additional factor in the formation of DNG in conditions of mild iodine deficiency. The unfavorable course of DNG occurs against the background of a decrease in the level of vitamin A, essential trace elements (Se and Zn) and excessive accumulation of toxic trace elements (Pb and Cd). Correction of vitamin-mineral imbalance is a necessary component of the treatment for DNG and prevention of its unfavorable course. In case of a decrease in the Se level, it is advisable to use the antioxidant complex OxyLyc, and in case of zinc deficiency, Zinkit is prescribed additionally.
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