Correlation of hypothyroidism and androgen deficiency in men of different periods of mature age

Main Article Content

T.I. Krytskyi
N.V. Pasiechko


Background. Combination of thyroid pathology with ыage-related androgen deficiency in men leads to the decline of sexual and reproductive functions, worsening the quality of life. The purpose was to reveal the features of correlation between the thyroid hypofunction and androgen deficiency in men in the first and second periods of mature age. Materials and methods. The study included 60 men with primary hypothyroidism aged 21 to 60 years. The enrollment of men for the examination was conducted during outpatient visits and hospital treatment in the endocrinology department of the University hospital of Ternopil. Results. In men of the first period of mature age, the incidence of hypogonadism was 22.2 %, including in men without hypothyroidism — 8.0 %, and with hypothyroidism — 40.0 %. In men with hypothyroidism, the incidence of androgen deficiency and its clinical signs was 5 times higher than that of patients without hypothyroidism. The presence of hypothyroidism in men of the second period of mature age is associated with androgen deficiency in 70 % cases, but, as compared to the men of the first period of mature age, the clinical signs of androgen deficiency are more severe in the second period. Conclusions. The presence of hypothyroidism erases the age-related differences in the content of total and free testosterone in the blood of men; the level of thyroid-stimulating hormone has the most significant negative effect on testosterone level in men of the first period of mature age.

Article Details

How to Cite
Krytskyi, T., and N. Pasiechko. “Correlation of Hypothyroidism and Androgen Deficiency in Men of Different Periods of Mature Age”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 14, no. 1, Mar. 2018, pp. 35-39, doi:10.22141/2224-0721.14.1.2018.127089.
Original Researches


Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010 Jun;95(6):2536-59. doi: 10.1210/jc.2009-2354.

Haddad RM, Kennedy CC, Caples SM, et al. Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007;82(1):29-39. doi: 10.4065/82.1.29.

Boloña ER, Uraga MV, Haddad RM, et al. Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007;82(1):20-28. doi: 10.4065/82.1.20.

Wu FC, Tajar A, Pye SR, et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45. doi: 10.1210/jc.2007-1972.

Araujo AB, Esche GR, Kupelian V, et al. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab. 2007;92(11):4241-4247. doi: 10.1210/jc.2007-1245.

Zitzmann M, Faber S, Nieschlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin Endocrinol Metab. 2006;91(11):4335-4343. doi: 10.1210/jc.2006-0401.

Hall SA, Esche GR, Araujo AB, et al. Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample. J Clin Endocrinol Metab. 2008 Oct;93(10):3870-7. doi: 10.1210/jc.2008-0021.

Travison TG, Araujo AB, Kupelian V, O'Donnell AB, McKinlay JB. The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. J Clin Endocrinol Metab. 2007;92(2):549-555. doi: 10.1210/jc.2006-1859.

Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006;60(7):762-769. doi: 10.1111/j.1742-1241.2006.00992.x.

Krassas GE, Tziomalos K, Papadopolou F, Pontikides N, Perros P. Erectile dysfunction in patients with hyper- and hypothyroidism: how common and should we treat. J Clin Endocrinol Metab. 2008 May;93(5):1815-9. doi: 10.1210/jc.2007-2259.

Kumar A, Shekhar S, Dhole B. Thyroid and male reproduction. Indian J Endocrinol Metab. 2014 Jan;18(1):23-31. doi: 10.4103/2230-8210.126523.

Most read articles by the same author(s)