Value of latent intracellular infection in the formation of autoimmune thyroiditis in women with polycystic ovary syndrome
Background. Mechanisms linking latent intracellular infection with autoimmune processes are being revealed to improve prevention of autoimmune diseases. Determining the incidence of latent chlamydial and herpesvirus infection in women with polycystic ovary syndrome (PCOS) and its association with the presence of autoimmune thyroiditis (AIT), thyroid dysfunction and sex hormone levels was the purpose of our study. Materials and methods. In 55 women aged 18–24 years with PCOS, the levels of total testosterone, progesterone, estradiol, thyroid stimulating hormone, free thyroxine, antibodies to thyroid peroxidase, to chlamydia and herpes simplex virus 1 and 2 types were evaluated, thyroid sonography was performed. The control group consisted of 20 healthy women of the same age. Results. In 21 women with PCOS, AIT occurred in the state of euthyroidism and with elevated levels of thyroid peroxidase antibodies; 14 women with AIT developed subclinical hypothyroidism, the remaining 20 patients with PCOS hadn’t thyroid pathology. Levels of total testosterone were significantly higher, estradiol and progesterone — significantly lower than in the control group. An increase in the level of chlamydia antibodies (> 1.1 IU) was established in 9.5 % of patients in the AIT group with euthyroidism, in 7.1 % — in the presence of subclinical hypothyroidism on the background of AIT, and in 5.0 % — in the absence of AIT. There is no significant difference between these subgroups. Antibodies to herpes simplex virus were increased, respectively, in 57.1, 64.3, 30.0 % of patients with PCOS and only in 20 % of women in the control group. Conclusions. The presence of latent herpesvirus infection in young women with PCOS can be a risk factor for AIT. In postmenopausal women, the imbalance of estrogen and progesteron can cause AIT.
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