Value of latent intracellular infection in the formation of autoimmune thyroiditis in women with polycystic ovary syndrome
Background. Mechanisms linking latent intracellular infection with autoimmune processes are being revealed to improve prevention of autoimmune diseases. Determining the incidence of latent chlamydial and herpesvirus infection in women with polycystic ovary syndrome (PCOS) and its association with the presence of autoimmune thyroiditis (AIT), thyroid dysfunction and sex hormone levels was the purpose of our study. Materials and methods. In 55 women aged 18–24 years with PCOS, the levels of total testosterone, progesterone, estradiol, thyroid stimulating hormone, free thyroxine, antibodies to thyroid peroxidase, to chlamydia and herpes simplex virus 1 and 2 types were evaluated, thyroid sonography was performed. The control group consisted of 20 healthy women of the same age. Results. In 21 women with PCOS, AIT occurred in the state of euthyroidism and with elevated levels of thyroid peroxidase antibodies; 14 women with AIT developed subclinical hypothyroidism, the remaining 20 patients with PCOS hadn’t thyroid pathology. Levels of total testosterone were significantly higher, estradiol and progesterone — significantly lower than in the control group. An increase in the level of chlamydia antibodies (> 1.1 IU) was established in 9.5 % of patients in the AIT group with euthyroidism, in 7.1 % — in the presence of subclinical hypothyroidism on the background of AIT, and in 5.0 % — in the absence of AIT. There is no significant difference between these subgroups. Antibodies to herpes simplex virus were increased, respectively, in 57.1, 64.3, 30.0 % of patients with PCOS and only in 20 % of women in the control group. Conclusions. The presence of latent herpesvirus infection in young women with PCOS can be a risk factor for AIT. In postmenopausal women, the imbalance of estrogen and progesteron can cause AIT.
Full Text:PDF (Українська)
Goncharova OA, Karachentsev IuI. Autoimmunnaia tireoidnaia patologiia [Autoimmune thyroid pathology]. Kyiv: Publisher Zaslavsky OYu; 2017. 212 p. (in Russian).
Deligeoroglou E, Vrachais N, Athanasopoulos N, at al. Mediators of chronic inflammatory markers in polycystic ovary syndrome. Gynecol Endocrinol. 2012 Dec;28(12):974-8. doi: 10.3109/09513590.2012.683082.
Escobar-Morreale FH, Luque-Ramirez M, Gonzalez F. Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertil Steril. 2011 Mar 1;95(3):1048-58.e1-2. doi: 10.1016/j.fertnstert.2010.11.036.
Morin-Papunen LC, Antoni J, Duleba A, Järvelin MR, Saikku P, Pouta A. Chlamydia antibodies and self-reported symptoms of oligo-amenorrea and hirsutism: a new etiologic factor in polycystic ovary syndrome? Fertil Steril. 2010 Oct;94(5):1799-804. doi: 10.1016/j.fertnstert.2009.10.021.
Hefler-Frischmuth K, Walch K, Huebl W, Baumuehlner K, Tempfer C, Hefler L. Serologic markers of autoimmunity in women with polycystic ovary syndrome. Fertil Steril. 2010 May 1;93(7):2291-4. doi: 10.1016/j.fertnstert.2009.01.056.
Novais JS, Benetti-Pinto CN, Garmes HM, Jales RM, Juliato CR. Polycystic ovary syndrome and chronic autoimmune thyroiditis. Gynecol Endocrinol. 2015 Jan;31(1):48-51. doi: 10.3109/09513590.2014.958990.
Arduc A, Aycicek Dogan B, Bilmez S, et al. High prevalence of Hashimoto's thyroiditis in patients with polycystic ovary syndrome: does the imbalance between estradiol and progesterone play a role? Endocr Res. 2015;40(4):204-10. doi: 10.3109/07435800.2015.1015730.
Honcharova OA. Associations between mycoplasma and components of immune response in women with autoimmune thyroiditis. Mìžnarodnij endokrinologìčnij žurnal. 2014;7(63):18-22. doi: 10.22141/2224-0718.104.22.1684.77122. (in Russian).
Janegova A, Janega P, Rychly B, Kuracinova K, Babal P. The role of Epstein-Barr virus infection in the development of autoimmune thyroid diseases. Endokrynol Pol. 2015;66(2):132-6. doi: 10.5603/EP.2015.0020.
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004 Jan;81(1):19-25. PMID: 14711538.
Canellada A, Alvarez I, Berod L, Gentile T. Estrogen and progesterone regulate the IL-6 signal transduction pathway in antibody secreting cell. J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):255-61. doi: 10.1016/j.jsbmb.2008.06.009.
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2019