Peculiarities of bariatric impact of Styfimol in patients with type 2 diabetes with obesity and hypertension

Main Article Content

K.O. Zuiev


Background. The purpose of the study was to eva­luate the impact of treatment with a fixed combination of extract of Garcinia cambogia, chromium picolinate, L-tyrosine, L-carnitine and dry extract of brown algae on anthropometric parameters, as well as the amount of adipose tissue (AT) and its distribution revealed by dual energy X-ray absorptiometry in patients with type 2 diabetes with obesity and arterial hypertension. Materials and methods. 53 patients (25 men) aged 55.90 ± 2.15 years with type 2 diabetes, arterial hypertension and obesity (body mass index (BMI) ≥ 30 kg/m2) were recruited in the study. Results. After 12 weeks of treatment with above-mentioned fixed combination at a dose of 1 capsule 3 times a day, a statistically significant reduction in body weight was observed — by 4.5 ± 0.6 % (P1 = 0.0001) and in BMI — by 4.60 ± 0.59 % (P1 = 0.0001), as well as a decrease in the total amount of AT by 4.16 ± 1.33 % (P1 = 0.003). Reduction in body weight occurred predominantly due to abdominal AT, as evidenced by a statistically significant decrease in the amount of AT in the abdominal compartment by 6.02 ± 10.15 % (P1 = 0.0003), as well as reduced waist circumference in both men and women by 6.73 ± 1.24 % (P1 = 0.0001) and 4.06 ± 0.77 % (P1 = 0.0009), respectively. Conclusions. Therapy with a fixed combination of Garcinia cambogia extract, chromium picolinate, L-tyrosine, L-carnitine and dry extract of brown algae has led to a decrease in body weight, mainly due to decrease of abdominal fat.

Article Details

How to Cite
Zuiev, K. “Peculiarities of Bariatric Impact of Styfimol in Patients With Type 2 Diabetes With Obesity and Hypertension”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 8, Dec. 2017, pp. 596-03, doi:10.22141/2224-0721.13.8.2017.119277.
To practicing Endocrinologists


World Health Organization (WHO). Global Status Report on Noncommunicable Diseases 2014. Available from:

World Health Organization (WHO). Noncommunicable diseases country profiles 2014. Available from:

Mitchenko OI, Mamedov MN, Kolesnyk TV, et al. Prevalence of Carbohydrate Metabolism Disorders in Urban Population of Ukraine Depending on the Degree and Type of Obesity. Mezhdunarodnyi Endokrinologicheskii Zhurnal. 2015;(68):11-16. (in Ukrainian).

Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes (Lond). 2011;35(7):891-8. doi: 10.1038/ijo.2010.222.

Ahmed A, Blackman MR, White M, Anker SD. Emphasis on abdominal obesity as a modifier of eplerenone effect in heart failure: hypothesis-generating signals from EMPHASIS-HF. Eur J Heart Fail. 2017;19(9):1198-1200. doi: 10.1002/ejhf.884.

Estampador AC, Franks PW. Precision Medicine in Obesity and Type 2 Diabetes: The Relevance of Early-Life Exposures. Clin Chem. 2017 Nov 2. pii: clinchem.2017.273540. doi: 10.1373/clinchem.2017.273540. [Epub ahead of print].

Shara M, Ohia SE, Schmidt RE. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Mol Cell Biochem. 2004 May;260(1-2):171-86. PMID: 15228099.

Ohia SE, Opere CA, LeDay, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem. 2002 Sep;238(1-2):89-103. PMID: 12349913.

Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. Curr Ther Res Clin Exp. 2003 Sep;64(8):551-67. doi: 10.1016/j.curtheres.2003.08.006.

Gürsel FE, Ateş A, Bilal T, Altiner A. Effect of Garcinia cambogia extract on body weight gain, feed intake and feed conversion ratio, and serum non-esterified fatty acids and C-reactive protein levels in rats fed with atherogenic diet. Biol Trace Elem Res. 2012 Sep;148(3):378-82. doi: 10.1007/s12011-012-9385-x.

Hao S, Avraham Y, Bonne O, Berry EM. Separation-induced body weight loss, impairment in alternation behavior, and autonomic tone: effects of tyrosine. Pharmacol Biochem Behav. 2001 Feb;68(2):273-81. doi: 10.1016/S0091-3057(00)00448-2.

Chinevere TD, Sawyer RD, Creer AR. Conlee RK, Parcell AC. Effects of L-tyrosine and carbohydrate ingestion on endurance exercise performance. J Appl Physiol (1985). 2002 Nov;93(5):1590-7. doi: 10.1152/japplphysiol.00625.2001.

Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus. Diabetes Technol Ther. 2006;8(6):677-687. doi: 10.1089/dia.2006.8.677.

Docherty JP, Sack DA, Roffman M, Finch M, Komorowski JR. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. J Psychiatr Pract. 2005;11(5):302-314. PMID: 16184071.

Korpachev VV, Khovaka VV. Stifimol as a new medicinal preparation for treatment of obesity with the well-proven clinical efficiency. Consilium Medicum Ukraina. 2008;2(5):34–36. (in Russian).

Zuyev KO. Impact of treatment with a fixed combination of extract of garcinia cambogia, chromium picolinate, L-tyrosine, L-carnitine and dry extract of brown algae on anthropometric parameters in patients with type 2 diabetes mellitus with obesity and arterial hypertension. Mezhdunarodnyi Endokrinologicheskii Zhurnal. 2013;(54):141-142. (in Ukrainian)