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Background. The purpose of the study was to evaluate the impact of treatment with a fixed combination of extract of Garcinia cambogia, chromium picolinate, L-tyrosine, L-carnitine and dry extract of brown algae on anthropometric parameters, as well as the amount of adipose tissue (AT) and its distribution revealed by dual energy X-ray absorptiometry in patients with type 2 diabetes with obesity and arterial hypertension. Materials and methods. 53 patients (25 men) aged 55.90 ± 2.15 years with type 2 diabetes, arterial hypertension and obesity (body mass index (BMI) ≥ 30 kg/m2) were recruited in the study. Results. After 12 weeks of treatment with above-mentioned fixed combination at a dose of 1 capsule 3 times a day, a statistically significant reduction in body weight was observed — by 4.5 ± 0.6 % (P1 = 0.0001) and in BMI — by 4.60 ± 0.59 % (P1 = 0.0001), as well as a decrease in the total amount of AT by 4.16 ± 1.33 % (P1 = 0.003). Reduction in body weight occurred predominantly due to abdominal AT, as evidenced by a statistically significant decrease in the amount of AT in the abdominal compartment by 6.02 ± 10.15 % (P1 = 0.0003), as well as reduced waist circumference in both men and women by 6.73 ± 1.24 % (P1 = 0.0001) and 4.06 ± 0.77 % (P1 = 0.0009), respectively. Conclusions. Therapy with a fixed combination of Garcinia cambogia extract, chromium picolinate, L-tyrosine, L-carnitine and dry extract of brown algae has led to a decrease in body weight, mainly due to decrease of abdominal fat.
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