Functional state of the pituitary-thyroid system in children with allergic dermatosis

T.V. Sorokman, I.Ya. Lozyuk, Lucas Daalder, V.G. Ostapchuk

Abstract


Background. Approximately 10 % of the pediatric population suffers from atopic dermatitis, and this disease is most common skin allergic pathology. The influence of thyroid hormones on the development of atopy is known. Study purpose was to evaluate the features of the functional status of the pituitary-thyroid system in children with allergic dermatosis. Materials and methods. 72 children aged from 7 to 18 years were divided into 4 groups: group I — patients who suffer from atopic dermatitis (n = 29), II — children with allergic contact dermatitis (n = 17), III group — patients with simple contact dermatitis (n = 16), IV group — healthy children (n = 10). The levels of thyroxine, thyroid stimulating hormone, antibodies to thyroglobulin (TG) were determined. Results. Erythema was found in 95.2 %, edema — in 43.5 %, exudation — in 37.1 %, excoriation — in 43.5 %, lichenification — in 56.4 % of the total group of patients. Dysfunctions of the pituitary-thyroid system, both at the central and peripheral level, were determined. The frequency of antibodies to TG detection in children of the first group was high and exceeded the average population values by 3.7 times (36.7 %, χ2 = 17.5, p < 0.05). The level of TG in all of observed patients was significantly higher than that of in the comparison group. The frequency of detection of antibo­dies to TG in the group of patients with the disease experience more than 10 years exceeded the average population values by 3.2 times (34.0 %, χ2 = 8.1, p < 0.05). Conclusions. Changes in the morpho-functional state of the pituitary-thyroid system, mainly of an autoimmune nature, are revealed in children with allergic dermatosis.


Keywords


children; pituitary-thyroid system; allergic dermatosis

References


Tanno LK, Torres MJ, Castells M, Demoly P; Joint Allergy Academies. What can we learn in drug allergy management from World Health Organization's International Classifications? Allergy. 2017 Nov 6. doi: 10.1111/all.13335.

Chu H, Shin JU, Park CO, Lee H, Lee J, Lee KH. Clinical diversity of atopic dermatitis: A review of 5,000 patients at a single institute. Allergy Asthma Immunol Res. 2017 Mar;9(2):158-168. doi: 10.4168/aair.2017.9.2.158.

Wahn U, Matricardi PM, Bieber T, et al. Food allergy in EAACI journals (2016). Pediatr Allergy Immunol. 2017 Oct 25. doi: 10.1111/pai.12830.

Celakovská J, Bukač J. Analysis of food allergy in atopic dermatitis patients-association with concomitant allergic diseases. Indian J Dermatol. 2014 Sep;59(5):445-50. doi: 10.4103/0019-5154.139867.

Wood RA. Advances in food allergy in 2015. J Allergy Clin Immunol. 2016 Dec;138(6):1541-1547. doi: 10.1016/j.jaci.2016.10.002.

Kim J, Kim H, Lim D, Lee YK, Kim JH. Effects of indoor air pollutants on atopic dermatitis. Int J Environ Res Public Health. 2016 Dec 9;13(12). pii: E1220. doi: 10.3390/ijerph13121220.

NIAID-Sponsored Expert Panel, Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the united states: summary of the NIAID-sponsored expert panel report. J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58. doi: 10.1016/j.jaci.2010.10.007.

Lee JH, Lee HS, Park MR. et al. Relationship between indoor air pollutant levels and residential environment in children with atopic dermatitis. Allergy Asthma Immunol Res. 2014 Nov;6(6):517-24. doi: 10.4168/aair.2014.6.6.517.

Mal'tseva TA. Features of functional state of thyroid status in patients with bronchial asthma (review). Bûlleten' fiziologii i patologii dyhaniâ. 2012;44:117-123. (in Russian).

Popova NV, Bondar` IA, Kudelia LM. Bronchial asthma features in initial hypothyroidism patients. Journal of Siberian Medical Sciences. 2010;5:6. (in Russian).

Kamaeva IA, Shaporova NL, Gaiduk IM. Clinical and immunological features of bronchial asthma accompanied by thyroid gland disorders. Meditsinskaya Immunologiya. 2013;15(2):147-154. (in Russian).




DOI: https://doi.org/10.22141/2224-0721.13.8.2017.119274

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