Main Article Content
Background. Approximately 10 % of the pediatric population suffers from atopic dermatitis, and this disease is most common skin allergic pathology. The influence of thyroid hormones on the development of atopy is known. Study purpose was to evaluate the features of the functional status of the pituitary-thyroid system in children with allergic dermatosis. Materials and methods. 72 children aged from 7 to 18 years were divided into 4 groups: group I — patients who suffer from atopic dermatitis (n = 29), II — children with allergic contact dermatitis (n = 17), III group — patients with simple contact dermatitis (n = 16), IV group — healthy children (n = 10). The levels of thyroxine, thyroid stimulating hormone, antibodies to thyroglobulin (TG) were determined. Results. Erythema was found in 95.2 %, edema — in 43.5 %, exudation — in 37.1 %, excoriation — in 43.5 %, lichenification — in 56.4 % of the total group of patients. Dysfunctions of the pituitary-thyroid system, both at the central and peripheral level, were determined. The frequency of antibodies to TG detection in children of the first group was high and exceeded the average population values by 3.7 times (36.7 %, χ2 = 17.5, p < 0.05). The level of TG in all of observed patients was significantly higher than that of in the comparison group. The frequency of detection of antibodies to TG in the group of patients with the disease experience more than 10 years exceeded the average population values by 3.2 times (34.0 %, χ2 = 8.1, p < 0.05). Conclusions. Changes in the morpho-functional state of the pituitary-thyroid system, mainly of an autoimmune nature, are revealed in children with allergic dermatosis.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
Tanno LK, Torres MJ, Castells M, Demoly P; Joint Allergy Academies. What can we learn in drug allergy management from World Health Organization's International Classifications? Allergy. 2017 Nov 6. doi: 10.1111/all.13335.
Chu H, Shin JU, Park CO, Lee H, Lee J, Lee KH. Clinical diversity of atopic dermatitis: A review of 5,000 patients at a single institute. Allergy Asthma Immunol Res. 2017 Mar;9(2):158-168. doi: 10.4168/aair.2017.9.2.158.
NIAID-Sponsored Expert Panel, Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the united states: summary of the NIAID-sponsored expert panel report. J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58. doi: 10.1016/j.jaci.2010.10.007.
Lee JH, Lee HS, Park MR. et al. Relationship between indoor air pollutant levels and residential environment in children with atopic dermatitis. Allergy Asthma Immunol Res. 2014 Nov;6(6):517-24. doi: 10.4168/aair.2014.6.6.517.