Vitamin D status, calcium, magnesium and parathyroid hormone levels in patients with diabetes mellitus
Background. The purpose was to investigate the levels of 25(OH)D, parathyroid hormone, ionized calcium and magnesium in patients with type 1 and type 2 diabetes mellitus (DM) by comparison to the group of healthy persons of corresponding age and sex. Materials and methods. The study included 40 persons divided into three groups: type 1 DM (n = 10, average age 43.0 ± 4.5 years), type 2 DM (n = 10, average age 55.0 ± 5.8 years), and control group of patients without DM of corresponding age and sex (n = 20, average age 53 years). Results. It has been found that the level of vitamin 25(OH)D is significantly lower in patients with type 1 and type 2 DM than in non-diabetics (p < 0.001). The parathyroid hormone content is significantly higher in the group of patients with type 1 DM as compared to healthy controls (p < 0.05). The difference between the level of parathyroid hormone in the group of patients with type 2 DM and in the group of people without diabetes is statistically insignificant. Also, in patients with type 2 DM, there is an imbalance of calcium and magnesium with a predisposition to hypercalcemia and hypomagnesaemia as compared to those without diabetes. Conclusions. Vitamin D deficiency is detected in all examined patients with type 1 DM. In patients with type 2 DM, vitamin D deficiency (in 70 %) and insufficiency (in 30 %) was also established. The data obtained regarding the level of these electrolytes require further investigation as to their clinical significance and testing in a larger sample of patients being studied.
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Hanley DA, Cranney A, Jones G, Whiting SJ, Leslie WD. Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. CMAJ. 2010 Sep 7;182(12):1315-1319. doi: 10.1503/cmaj.091062.
Povorozniuk V, Pankiv I. Vitamin D Status in Population of Bukovyna and Subcarpathia Depending on Residence above Sea Level. Bol', Sustavy, Pozvonochnik. 2016;2(22):7-10. doi: 10.22141/2224-1507.2.22.2016.75755. (in Ukrainian).
Scragg R, Sowers M, Bell C; Third National Health and Nutrition Examination Survey. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004 Dec;27(12):2813-8. PMID: 15562190.
Forouhi NG, Luan J, Hennings S, Wareham NJ. Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990–2000. Diabet Med. 2007 Feb;24(2):200-7. doi: 10.1111/j.1464-5491.2007.02068.x.
Hyppönen E, Läärä E, Reunanen A , Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001 Nov 3;358(9292):1500-3. doi: 10.1016/S0140-6736(01)06580-1.
Pitocco D, Crino A, Di Stasio E, et al. The effects of calcitriol and nicotinamide on residual pancreatic β‐cell function in patients with recent‐onset Type 1 diabetes (IMDIAB XI). Diabet Med. 2006 Aug;23(8):920-3. doi: 10.1111/j.1464-5491.2006.01921.x.
Pham P-C, Pham P-M, Pham P-A, et al. Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2. Clin Nephrol. 2005 Jun;63(6):429-36. PMID: 15960144.
Malik RA, Mehta P, Bhat AA, et al. Vitamin D Receptor (VDR) Gene Polymorphism and Type 2 Diabetes mellitus - A Case Control Study in Ethnic Population of Kashmir Valley. Adv Res Gastroentero Hepatol 4(5): ARGH.MS.ID.555648. doi: 10.19080/ARGH.2017.04.555648.
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