Dynamics of thyroid gland sizes in patients with diffuse and nodular goiter, autoimmune thyroiditis during monotherapy by Alba® preparation in different regions of Ukraine
Background. The purpose of work was to evaluate the dynamics of thyroid volume in patients with autoimmune thyroiditis (АТ), diffuse non-toxic goiter (DNG) and nodular goiter (NG) during monotherapy by herbal preparation Alba® in the different regions of Ukraine. Materials and methods. Research was conducted by endocrinologists in 56 medical institutions of Ukraine. There were patients with АТ, DNG and NG under supervision. Patients received monotherapy by preparation of Alba® during six months at a dose of one capsule twice a day. Before treatment, after 3 and 6 months, thyroid volume (in сm3) was evaluated. Results. Probability of thyroid volume reduction (by 15 % and more for 6 months) in patients with АТ on the background of treatment using Alba® is related to the initial thyroid volume. Probability of achieving the effect grows (p = 0.001, odds ratio (OR) = 1.07; 95% confidence interval (CI) 1.03–1.11) on each 1 сm3 of initial volume increase. Probability of thyroid volume reduction (by 15 % and more for 6 months) in patients with DNG after application of Alba® is related to the initial thyroid volume. Probability of achieving the effect grows (p < 0.001, OR = 1.09; 95% CI 1.04–1.14) on each 1 cм3 increase of initial volume. Conclusions. The clinical efficiency of Alba® preparation in terms of reducing thyroid volume was proved in patients with АТ, DNG and NG.
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Balabolkin MI, Klebanova EM, Kreminskaia VM, authors. Fundamental'naia i klinicheskaia tiroidologiia [Basic and clinical thyroidology]. Мoscow: Meditsina; 2007. 816 p. (in Russian).
Pan'kiv VI. Praktychna tyreoi'dologija [Practical thyroidology]. Donetsk: Publisher Zaslavsky OYu; 2011. 224 p. (in Ukrainian).
Gromova OA, Torshin IIu, Kosheleva NG. Molecular iodine sinegists: new aspects of effective prevention and therapy of iodine deficiency disorders in pregnant women. RMJ. 2011;19(1):51-58. (in Russian).
Kaminskyi OV, Afanasyev DY, Kovalenko OM, Tepla OV, Cheren'ko SM, authors. Kaminskyi OV, editor. Standarty nadannja medychnoi' dopomogy hvorym z patologichnymy stanamy shhytopodibnoi' zalozy v umovah dii' negatyvnyh chynnykiv dovkillja: metodychnyj posibnyk [Standards of medical care to the patients with thyroid pathology in the conditions of action of negative environment factors: toolkit]. Kyiv: Limited Company Den' pechati; 2012. 164 p. (in Ukrainian).
Mamenko MYe, Yerohina OI, Golovchenko NM. Prophylaxis and treatment of the endemic goiter in the areas with high prevalence of iodine and iron deficiency. Ukrai'ns'kyj medychnyj al'manah. 2008;11(5):101-104. (in Ukrainian).
Voloshyn OI, Vasjuk VL, Malkovych NM, Senjuk BP, authors. Voloshyn OI, editor. Osnovy fitoterapii' ta gomeopatii' [Bases of phytotherapy and homoeopathy]. Vyzhnytsia: Cheremosh; 2011. 628 p. (in Ukrainian).
Semenova EF, Presniakova EV. Chemical composition of Potentilla alba and its application in practical medicine. Chemistry and Computational Simulation. Butlerov Communications. 2001;2(5):32-34. (in Russian).
Lyakh YuE, Gurianov VG, Khomenko VN, Panchenko OA, authors. Osnovy komp'iuternoi biostatistiki: analiz informatsii v biologii, meditsine i farmatsii statisticheskim paketom Medstat [Bases of computer biostatistics: analysis of information in biology, medicine and pharmacy by the statistical package of Medstat]. Donetsk: Papakitsa EK; 2006. 214 p. (in Russian).
Turchaninova LI. Experience of using phytopreparation Alba® (root extract of the potentilla alba) in complex treatment of thyroid pathology in children and adolescent. Likars'ka sprava. 2014;3-4:125-129. (in Russian).
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