Effect of vitamin D supplementation on insulin resistance in patients with hypothyroidism
Background. Over the past decade, numerous non-skeletal diseases have been reported to be associated with vitamin D deficiency, including autoimmune thyroid pathology. Different studies provide evidence that vitamin D may play a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity. The effect of vitamin D supplementation on insulin resistance in patients with hypothyroidism has not been investigated. The purpose of the study is to evaluate the effects of vitamin D supplementation on insulin resistance in hypothyroidism. Materials and methods. 47 participants, 32–74 years old, including 39 women (82.9 %) and 8 men (17.1 %), took part in the study. Serum thyroid-stimulating hormone, insulin and 25(OH)D concentration were measured, and HOMA-IR was calculated. All measurements were performed at the beginning and the end of the study. Patients with hypothyroidism received 21,000 IU of cholecalciferol orally per week for twelve weeks. The results were analyzed by descriptive tests, and a comparison between variables was made using paired T-tests or Wilcoxon tests, as an appropriate. Results. All of the participants were vitamin D deficient. Mean serum 25(OH)D concentration was 21.72 ± 6.14 ng/ml. The results at baseline and at the end were: for insulin — 19.36 ± 2.39 and 9.92 ± 2.38 mIU/L (p < 0.05) and for HOMA-IR — 3.91 ± 0.32 and 2.38 ± 0.17 (p < 0.05), respectively. Conclusions. Our data showed significant improvement in serum insulin and in HOMA-IR after treatment with cholecalciferol, suggested that vitamin D supplementation could reduce insulin resistance in hypothyroidism.
Palomer X, Gonzalez-Clemente JM, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab. 2008;10(3):185-97. doi: 10.1111/j.1463-1326.2007.00710.x.
Maestro B, Molero S, Bajo S, Dávila N, Calle C. Transcriptional activation of the human insulin receptor gene by 1, 25-dihydroxyvitamin D(3). Cell Biochem Funct. 2002;20(3):227-32. doi: 10.1002/cbf.951.
Tanabe N, Saito K, Yamada Y, Takasawa T, Seki N, Suzuki H. Risk assessment by post-challenge plasma glucose, insulin response ratio, and other indices of insulin resistance and/or secretion for predicting the development of type 2 diabetes. Inter Med. 2009;48:401-9. doi: 10.2169/internalmedicine.48.1325.
von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr. 2010 Feb;103(4):549-55. doi: 10.1017/S0007114509992017.
Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in non-diabetic adults. Diabetes Care. 2007;30(4):980-6. doi: 10.2337/dc06-1994.
Witham MD, Dore FJ, Druburgh M, Sugden JA, Morris AD, Struthers AD. The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial. Diabetologia. 2010;53(10):2112-9. doi: 10.1007/s00125-010-1838-1.
Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabetic Medicine. 2009;26(1):19-27. doi: 10.1111/j.1464-5491.2008.02636.x.
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