Pharmacotherapeutic efficiency and advantages of the combined treatment of patients with type 2 diabetes mellitus
Keywords:type 2 diabetes mellitus, treatment, metformin, glimepiride
Background. The early prescription of a combination of extended-release metformin with glimepiride influencing different links of the pathogenesis of type 2 diabetes mellitus (DM) is grounded in the article. The purpose of the research was to evaluate the dynamics of glycated haemoglobin (HbA1c) after the period of supervision as compared to the baseline, and also to determine additional parameters of efficiency, safety, and tolerability of Duglimax manufactured by Кusum Pharm (Ukraine) in the therapy of type 2 DM. Materials and methods. The study included 46 patients with type 2 DM divided into two groups. For the patients of the first group (n = 26), who previously received metformin preparations at a dose of up to 2000 mg/day, the combined preparation Duglimax (metformin 500 mg and glimepiride 2 mg) was prescribed, and also extended-release metformin (Metamin SR) in the evening. The patients of the second group (n = 20) continued the reception of extended-release metformin twice daily in a dose of 2000–2500 mg/day. Results. After 12 weeks of therapy, in patients of the first group, the level of НbА1с significantly decreased to 6.72 ± 0.29 %. The level of insulin in the first group was 14.06 ± 1.81 mIU/ml after treatment (in baseline level of 19.17 ± 2.05 mIU/ml), HOMA-IR — 3.14 ± 0.21 (vs initial one of 5.92 ± 1.46). Results of the clinical study show the absence of hypoglycemia development in patients receiving Duglimax during the follow-up period. Conclusions. Combined antidiabetic therapy with Duglimax for 12 weeks results in the substantial decrease of HbA1c level and achievement of target indexes of carbohydrate metabolism in type 2 DM patients. The good tolerability and high safety of Duglimax were registered during the period of supervision.
Palomer X, Gonzalez-Clemente JM, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab. 2008;10(3):185-97. doi: 10.1111/j.1463-1326.2007.00710.x.
Maestro B, Molero S, Bajo S, Dávila N, Calle C. Transcriptional activation of the human insulin receptor gene by 1, 25-dihydroxyvitamin D(3). Cell Biochem Funct. 2002;20(3):227-32. doi: 10.1002/cbf.951.
Tanabe N, Saito K, Yamada Y, Takasawa T, Seki N, Suzuki H. Risk assessment by post-challenge plasma glucose, insulin response ratio, and other indices of insulin resistance and/or secretion for predicting the development of type 2 diabetes. Inter Med. 2009;48:401-9. doi: 10.2169/internalmedicine.48.1325.
von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr. 2010 Feb;103(4):549-55. doi: 10.1017/S0007114509992017.
Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in non-diabetic adults. Diabetes Care. 2007;30(4):980-6. doi: 10.2337/dc06-1994.
Witham MD, Dore FJ, Druburgh M, Sugden JA, Morris AD, Struthers AD. The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial. Diabetologia. 2010;53(10):2112-9. doi: 10.1007/s00125-010-1838-1.
Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabetic Medicine. 2009;26(1):19-27. doi: 10.1111/j.1464-5491.2008.02636.x.
Copyright (c) 2020 V.I. Pankiv
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.