Mathematical model of diabetic encephalopathy in diagnosis of complicated forms of diabetes mellitus
Background. The purpose of this research is to optimize the methods for diagnosis of diabetic encephalopathy based on the study of indicators of cerebrovascular hemodynamics, functional state of the brain, metabolic disorders and morphological characteristics of the brain tissue. Materials and methods. A comprehensive survey was carried out in 537 patients with diabetes mellitus (DM), including 342 (63.7 %) persons with type 1 DM, and 195 (36.3 %) — with type 2 DM. Results. The article presents data on the integrated study of clinical, metabolic and functional indicators as risk factors for diabetic encephalopathy. Their diagnostic significance is argued. On the basis of a comprehensive assessment of the obtained data, which expanded the view on the pathogenesis of diabetic encephalopathy, the priority of metabolic disorders was confirmed. Diagnostic criteria of diabetic encephalopathy were established and its mathematical model was developed. Conclusions. The availability of informative indicators identified will allow the doctor to diagnose diabetic encephalopathy at the early stages or to predict its development and to detect at the preclinical stage.
Francis GJ, Martinez JA, Liu WQ, et al. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type 1 diabetic encephalopathy. Brain. 2008 Dec;131(Pt 12):3311-34. doi: 10.1093/brain/awn288.
Malone JI, Hanna S, Saporta S, et al. Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatr Diabetes. 2008 Dec;9(6):531-9. doi: 10.1111/j.1399-5448.2008.00431.x.
Perantie DC, Wu J, Koller JM, et al. Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Diabetes Care. 2007 Sep;30(9):2331-7. doi: 10.2337/dc07-0351.
Ho MS, Weller NJ, Ives FJ, et al. Prevalence of structural central nervous system abnormalities in early-onset type 1 diabetes mellitus. J Pediatr. 2008 Sep;153(3):385-90. doi: 10.1016/j.jpeds.2008.03.005.
Salem MA, Matta LF, Tantawy AA, et al. Single photon emission tomography (SPECT) study of regional cerebral blood flow in normoalbuminuric children and adolescents with type 1 diabetes. Pediatr Diabetes. 2002 Sep;3(3):155-62. doi: 10.1034/j.1399-5448.2002.30306.x.
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