Violations of macro- and micronutrient support in patients with nodular thyroid pathology from regions injured after the Chornobyl accident

V.I. Kravchenko, I.A. Luzanchuk, I.N. Andrusyshyna, O.M. Golinko, I.O. Golub

Abstract


Background. The purpose of our study was to determine the state of macro- and micronutrient support of patients with nodular thyroid pathology from the regions injured after the Chornobyl accident. Materials and methods. 65 habitants of the Chernihiv area were examined: 40 — without thyroid pathology (15 men and 25 women) aged 36.62 ± 0.60 years, and 25 (5 men and 20 women) — with the diagnosed nodular goiter. Results. Research of urinary iodine excretion showed that a median in the control group was 95.6 µg/l, among patients with nodular goiter — 89.3 µg/l, indicating the presence of moderate iodine deficiency. Blood thyroglobulin level in patients of control group was 9.26 ± 0.99 ng/l, among patients with nodular goiter — 23.03 ± 4.70 ng/l. Thyroid-stimulating hormone level higher than 4.0 mIU/l was in 8.9 % of patients with nodular goiter and in 5.0 % of persons from the control group. The data of ultrasonic researches demonstrated that the average thyroid volume in patients of control group was 10.1 ± 0.3 cm3, among patients with nodular goiter — 18.6 ± 1.7 cm3. In the group of patients with nodular goiter, the decreased (p < 0.0001) level of macronutrients in blood plasma was detected: calcium was 67.26 ± 3.21 µg/l and magnesium — 14.88 ± 0.35 µg/l, as well as of microelements: zinc content was 0.72 ± 0.04 µg/l (p < 0.0001) and iron — 0.54 ± 0.06 µg/l (p < 0.05), in comparison with the results in the control group. Conclusions. The relative risk (χ2 criterion for the four-course table of connectivity with Fisher’s correction) of nodular goiter development at subzero content of calcium was 2.24 (95% confidence interval (CI) 1.58–2.61), the risk of nodular goiter development at subzero levels of magnesium — 2.56 (95% CI 1.77–3.03).


Keywords


iodine deficiency; thyroid gland; nodular goiter; urinary iodine excretion; macro- and microelements

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DOI: https://doi.org/10.22141/2224-0721.13.6.2017.112879

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