Main Article Content
Background. Vitamin D and its metabolites play an important clinical role due to their interrelationship with calcium homeostasis and bone metabolism. Vitamin D has major effects on nearly all cells of the immune system. The purpose of this study was to evaluate the association between autoimmune thyroiditis (AT) and vitamin D deficiency. Materials and methods. A total of 376 female subjects were included, of whom 52 and 324 participants were healthy or had vitamin D deficiency, respectively. Serum vitamin D levels, parathyroid hormone concentrations, thyroid hormone levels and thyroid auto-antibodies were measured in all subjects. Results. Demographic characteristics of participants were not significantly different between the control and study groups (p > 0.05). Incidence of AT appeared to be significantly higher in the group of women with vitamin D insufficiency and deficiency. A level of thyroid auto-antibodies was in reliable correlation with maintenance of vitamin D. Conclusions. AT was found to be associated with vitamin D deficiency in female patients in this study.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30. doi: 10.1210/jc.2011-0385.
D’Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev. 2015;14:363-9. doi: 10.1016/j.autrev.2014.10.008.
Shin DY, Kim KJ, Kim D, Hwang S, Lee EJ. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J. 2014 Mar;55(2):476-81. doi: 10.3349/ymj.2014.55.2.476.
Mansournia N, Mansournia MA, Saeedi S, Dehghan J. The association between serum 25OHD levels and hypothyroid Hashimoto’s thyroiditis J Endocrinol Invest. 2014 May;37(5):473-6. doi: 10.1007/s40618-014-0064-y.
Barchetta I, Baroni MG, Leonetti F, et al. TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adultsClin Exp Med. 2015 Aug;15(3):389-96. doi: 10.1007/s10238-014-0290-9.