Prevalence of autoimmune thyroiditis among women with vitamin D deficiency
Background. Vitamin D and its metabolites play an important clinical role due to their interrelationship with calcium homeostasis and bone metabolism. Vitamin D has major effects on nearly all cells of the immune system. The purpose of this study was to evaluate the association between autoimmune thyroiditis (AT) and vitamin D deficiency. Materials and methods. A total of 376 female subjects were included, of whom 52 and 324 participants were healthy or had vitamin D deficiency, respectively. Serum vitamin D levels, parathyroid hormone concentrations, thyroid hormone levels and thyroid auto-antibodies were measured in all subjects. Results. Demographic characteristics of participants were not significantly different between the control and study groups (p > 0.05). Incidence of AT appeared to be significantly higher in the group of women with vitamin D insufficiency and deficiency. A level of thyroid auto-antibodies was in reliable correlation with maintenance of vitamin D. Conclusions. AT was found to be associated with vitamin D deficiency in female patients in this study.
Full Text:PDF (Українська)
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30. doi: 10.1210/jc.2011-0385.
D’Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev. 2015;14:363-9. doi: 10.1016/j.autrev.2014.10.008.
Shin DY, Kim KJ, Kim D, Hwang S, Lee EJ. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J. 2014 Mar;55(2):476-81. doi: 10.3349/ymj.2014.55.2.476.
Mansournia N, Mansournia MA, Saeedi S, Dehghan J. The association between serum 25OHD levels and hypothyroid Hashimoto’s thyroiditis J Endocrinol Invest. 2014 May;37(5):473-6. doi: 10.1007/s40618-014-0064-y.
Barchetta I, Baroni MG, Leonetti F, et al. TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adultsClin Exp Med. 2015 Aug;15(3):389-96. doi: 10.1007/s10238-014-0290-9.
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2020