Thyroid pathology in patients with acromegaly: review of literature and own researches

Yu.V. Buldygina, H.M. Terekhova, M.Yu. Bolgov, T.V. Fedko

Abstract


The analysis of medical scientific literature and retrospective analysis were performed using medical documents of patients treated in the cliniс of the State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, in order to study a thyroid pathology in acromegalic patients. In accordance with data of international studies, the multinodular goiter constitutes the biggest part in the structure of thyroid pathology of acromegalic patients, and the incidence of thyroid cancer ranges from 3 to 12.5 %. Among acromegalic patients who were treated in this clinic, the thyroid pathology was observed in 97.7 % of patients, and the part of multinodular goiter made up 51.2 %, autoimmune thyroiditis — 13.9 %, thyroid cancer — 4.6 %. It may be concluded that it is necessary to evaluate on a constant basis the condition of thyroid gland in acromegalic patients for timely diagnosis and treatment, especially in terms of thyroid cancer risk.


Keywords


acromegaly; multinodular goiter; thyroid cancer

References


Pronin VS, Chubrova NA., Pronin EV, Kotliarevskaya EI. Prevalence and curative manual in acromegaly. Meditsinskiy sovet. 2014;11:70-4. (In Russian). doi: 10.21518/2079-701X-2014-11-70-75.

Herrmann BL, Baumann H, Janssen OE, Gorges R, Schmid KW, Mann K. Impact of disease activity on thyroid disease in patients with acromegaly: basal evaluation and follow-up. Exp Clin Endocrinol Diabetes. 2004;112(5):225-30. doi: 10.1055/s-2004-817967.

Cheung NW, Boyages SC. The thyroid gland in acromegaly: an ultrasonographic study. Clin Endocrinol (Oxf). 1997 May;46(5):545-9. PMID: 9231049.

Scacchi M, Andrioli M, Carzaniga C. et al. Elastosonographic evaluation of thyroid nodules in acromegaly. Eur J Endocrinol. 2009;161:607-13. doi: 10.1530/eje-09-0558.

Tramontano D, Cushing GW, Moses AC, Ingbar SH. Insulin-like growth factor-1 stimulates the growth of rat thyroid cells in culture and synergizes the stimulation of DNA synthesis introduced by TSH and Graves′-IgG. Endocrinology. 1986 Aug;119(2):6940-2. doi: 10.1210/endo-119-2-940.

Miyakawa M, Sagi M, Tsushima T, Wakai K, Shisume K. Thyroid volume and serum thyroglobulin levels in patients with acromegaly; correlation with plasma insulin-like growth factor I levels. J Clin Endocrinol Metab. 1988 Nov;67(5):215-20. doi: 10.1210/jcem-67-5-973.

Wolinski K, Czarnywojtek A, Ruchala M. Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly – meta-analysis and systematic review. PLoS One. 2014 Feb;9(2):e88787. doi: 10.1371/journal.pone.0088787.

Dogan S, Atmaka A, Dagdelen S, Erbas B, Erbas T. Evaluation of thyroid diseases and differentiated thyroid cancer in acromegalic patients. Endocrine. 2014;45(1):114-121. doi: 10.1007/s12020-013-9981-3.

Uchoa HB, Lima GA, Correa LL, Vsdal AP, Cavallieri SA, Vaisman V, Buesku A, Gadelha MR. Prevalence of thyroid disease in patients with acromegaly: experience of a Brazilian center. Arq Brazil Endocrinol Metab. 2013;57(9):685-90. doi: 10.1590/S0004-27302013000900003.

Kniazeva OV, Molitvoslovova NN, Rozhinskaya LYa. Prevalence of newly diagnosed thyroid formations. Klinicheskaya i eksperimental’naya tireoidologiya. 2015;11(3):34-37. (In Russian).




DOI: https://doi.org/10.22141/2224-0721.13.4.2017.106655

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru