Vaspin is a compensatory molecule in the pathogenesis of metabolic obesity-induced disorders
Background. The development of disabling effects in obesity is connected to the functioning disorders of adipose tissue hormones — the adipokines, including vaspin. The nature of changes in vaspin content in Ukrainians with different body weight requires further investigation. The purpose was to investigate vaspin content in circulating blood in Kharkіv citizens, depending on the body mass index, degree and topography of adipose tissue deposit, blood insulin levels, the index of insulin resistance HOMA and adipose tissue level. Materials and methods. Content of vaspin in circulation in 250 people aged 65.48 ± 11.86 years has been defined by imunnoenzyme method. The nature of the relationship between vaspin and the body mass index, waist and thigh circumference, fat content, blood insulin levels and insulin resistance index HOMA were evaluated. Results. The blood vaspin level was found to depends on the relative content of adipose tissue. Decreased sensitivity of tissues to insulin (NOMA-index more than 4.00) among representatives of the Ukrainian population is accompanied by increased blood vaspin more than 650 ng/ml. Conclusions. The perspective direction is to detect reasons of gender differences in vaspin level in obesity.
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Lu Y, Hajifathalian K, Ezzati M, et al. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1-8 million participants. Lancet. 2014;383(9921):970-83. doi: 10.1016/S0140-6736 (13)61836-X.
Rоmеrо-Corrali A, Montori VM, Somers VK, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006;368:666-678. doi: 10.1016/S0140-6736(06)69251-9.
Masters RK, Reither EN, Powers DA, et al. The impact of obesity on US mortality levels: the importance of age and cohort factors in population estimates. Am J Public Health. 2013;103(10):1895-901. doi: 10.2105/AJPH.2013.301379.
Wang XH, Dou LZ, Gu C, et al. Plasma levels of omentin-1 and visfatin in senile patients with coronary heart disease and heart failure. Trop Med. 2014 Jan;7(1):55-62. doi: 10.1016/S1995-7645(13)60192-3.
Mm WQ, Fan J, Khor S, et al. Serum vaspin levels and vaspin mRNA expression in subcutaneous adipose tissue in women with gestational diabetes mellitus. Eur J Obstet Gynecol Reprod Biol. 2014 Nov;182:98-101. doi: 10.1016/j.ejogrb.2014.09.008.
Feng R, Li Y, Wang C, et al. Higher vaspin levels in subjects with obesity and type 2 diabetes mellitus: a meta-analysis. Diabetes Res Clin Pract. 2014 Oct;106(1):88-94. doi: 10.1016/j.diabres.2014.07.026.
Yan M, Su B, Peng W, et al. Association of serum vaspin and adiponectin levels with renal function in patients with or without type 2 diabetes mellitus. J Diabetes Res. 2014;2014:86-7. doi: 10.1155/2014/868732.
Kravchun PG, Kravchun PP. The value of adipocytokines in development and progress of chronic heart failure in patients with post-infarction cardiosclerosis and type 2 diabetes. Meditsina (Kazakhstan). 2015;1(151):5-9. (In Russian).
Choi SH, Kwak SH, Lee Y, et al. Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women. Clin Endocrinol. (Oxf). 2011 Nov;75(5):628-35. doi: 10.1111/j.1365-2265.2011.04095.x.
Hida K, Wada J, Eguchi J, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA. 2005;102(30):10610-5. doi: 10.1073/pnas.0504703102.
Wada J. Vaspin and insulin resistance. Rinsho Byori. 2008;56(8):705-11. (In Japanese). PMID: 18800627.
Wang YM, Wang WP, Wang LP, et al. Calorie control increased vaspin levels of serum and periepididymal adipose tissue in diet-induced obese rats in association with serum free fatty acid and tumor necrosis factor alpha. Chin Med J (Engl). 2010 Apr;123(7):936-41. PMID: 20497691.
Nakatsuka A, Wada J, Iseda I, et al. Visceral adipose tissue-derived serine proteinase inhibitor inhibits apoptosis of endothelial cells as a ligand for the cell-surface GRP78/voltage-dependent anion channel complex. Circulation Res. 2013;112(5):771-80. PubMed: 23307819. doi: 10.1161/circresaha.111.300049.
Kravchun NA, Kazakov AV, Karachentsev YuI, et al, authors. Saharnyj diabet 2 tipa: skrining i faktory riska [Type 2 diabetes mellitus: screening and risk factors]. Kharkiv: Novoe slovo; 2010. 256 p. (In Russian).
Rudnev SG, Soboleva NP, Sterlikov SA, et al, authors. Bioimpedansnoe issledovanie sostava tela naselenija Rossii [Bioimpedance research of body composition of Russian population]. Мoscow: RIO TSIIOIZ; 2014. 493 p. (In Russian).
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