Historical aspects of endocrinology development

M.D. Tronko, Ya.H. Balon, O.Ya. Samson

Abstract


The historical data on the development of medicine as a science, with an emphasis on aspects of the endocrinology, are given in this paper. The role of Ukrainian and foreign scientists and their contribution to the development of the chemistry of hormones has been clarified in a historical context. The role of schools, academies in shaping the outlook of future scientists and the promotion of best practices is shown. The article shows how the knowledge of medicine was gradually accumulated: clinical manifestations, definition of laboratory differences. The ability to provide pathogenetic treatment to the patient with endocrine disease was possible in most cases only after the industrial synthesis of hormones. The works of many scientists were awarded the Nobel Prize in medicine and physiology. The definition of “hormone”, classification, place of biosynthesis, particularly of the secretion, the industrial synthesis of some of them and the scope of use are presented. Special attention is paid to the description of new methods of synthesis of thyroxine, flutapharm and other substances.

Keywords


endocrinology; hormone; history; biosynthesis; regulation

References


Tronko MD, Bodnar PM, Komisarenko YuI. Іstorіja rozvitku endokrinologії v Ukraїnі [History of Endocrinology in Ukraine]. Kyiv: Zdorov’ya; 2004. 68 p. (In Ukrainian).

Bodnar PM. Endokrinologіja [Endocrinology]. Kyiv: Zdorov’ya; 2003. 512 p. (In Ukrainian).

Zak KP, Popova VV. The prediction of type 1 diabetes development and diagnosis of its asymptomatic phase using autoantibodies to human islets of Langerhans long before the onset of the disease. Mezhdunarodnyiy Endokrinologicheskii Zhurnal. 2016;7(79):11-21. (In Russian). doi: 10.22141/2224-0721.7.79.2016.86414.

Isaak OD, Balion YaG, Isaak VO. Hіmіja prirodnih spoluk [Chemistry of natural connections]. Lugansk: NoulIdzh; 2012. 756 p. (In Ukrainian).

Balon YaG, Simurov OV, Samson OYa. General principles of creation of medicinal facilities. Influence of some elements and basic functional groups on biological activity of compounds. Naukoviy Vіsnik Chernivetskogo Unіversitetu. 2015;768:58-64. (in Ukrainian).

Balion YaG, Simurov OV, Brobarets VS, et al. New approach to the synthesis of 3,5,3'-triiod-4'hydroxyphenyl acid. Zhurnal farmacevtichnoї ta organіchnoї hіmіi. 2005;3(11):48-51. (In Ukrainian).

Balion YaG, Simurov OV. Thyroid hormones production. Zhurnal farmacevtichnoї ta organіchnoї hіmіi. 2004;2(6):48-51. (in Ukrainian)

KravchenkoV.I. Chornobyl accident and iodine defficiency as risk of thyroid pathology factors in population of the affected regions of Ukraine. Mezhdunarodnyiy Endokrinologicheskii Zhurnal. 2016;2(74):13-20. (In Ukrainian). doi: 10.22141/2224-0721.2.74.2016.70911.

Karachentsev YuI. Main ways of development of the Ukrainian scientific and Research Institute of pharmacotherapу of endocrine disease during 80 yers (1919-1999). Endokrinologіya. 1996;1(1):25-31. (In Ukrainian).

Komіsarenko VP. Some conclusions of development of endocrinology in Ukraine. Fіzіologіchniy zhurnal. 1967;5:189-200. (In Ukrainian).

Tronko ND, Komisarenko IV, Kovalenko AE, Omelchuk AV. Papillary thyroid carcinoma in Ukraine in the period after Chernobyl accident. Endokrinologіya. 2011;16(1):4-12. (In Ukrainian).

Komisarenko VP, Reznikov AG. Ingibitory funkcii kory nadpochechnikov [Inhibitors of adrenal function]. Kyiv: Zdorov’ya; 1972. 374 p. (In Russian).

Balion YaG. Pharmacotherapy of adrenal pathology. Zhurnal organіchnoуi ta farmatsevtichnoуi hіmіуi. 2009;10(37):19-29. (In Ukrainian).

Balion YaG, Korpachev VV. Some researches in creation of medicinal facilities for treatment of endocrine pathology. Endokrinologіya. 1996;1(1):25-31. (in Ukrainian).

ReznikovA.G. V mire gormonov [In the world of hormones]. Kyiv: Naukova dumka; 1985. 165 p. (In Russian).

Tronko MD, Komіsarenko IV, Balion YaG. Inhibitors of adrenal hormones and their applications in clinical practice. Zhurnal AMN Ukraуini. 2010;16(2):271-278. (In Ukrainian).

Reznikov AG, Varga SV. Antiandrogenes. Problemy endokrinologii. 1979;23(2):79-86. (In Russian).

Balyon YaG, Varga SV, Reznikov AG. Synthesis and antiandrogenic activity of substituted for karboksanilides. Himicheskij farmacevticheskij zhurnal.1987;6:681-5. (In Russian).

Balyon YaG, Sіmurov OV, Sіmurov NV. Synthesis and androgenic activity of N-arilamides of carboxylic acids. Zhurnal organіchnoуi ta farmatsevtichnoуi hіmіуi. 2008;7(28):41-6. (In Ukrainian).




DOI: https://doi.org/10.22141/2224-0721.13.3.2017.104472

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru