Dyshormonal states of the reproductive system in women after thyroidectomy and radioiodine therapy for differentiated thyroid carcinoma

A.M. Kvachenyuk, T.M. Kuchmenko, Yu.M. Bozhok, A.V. Zelinskaya, Ye.A. Shelkovoy

Abstract


Using ultrasound data and content of gonadotropin and sex hormones in the blood, the morphological and functional state of the mammary glands, the uterus and the ovaries were studied in women after thyroidectomy and radioiodine therapy, who were taken suppressive therapy with levothyroxine drugs that allows to estimate the hormonal supply of the menstrual cycle and the state of reproductive system. The signs of menstrual cycle disorders and luteal phase deficiency were revealed during the treatment, and dyshormonal hyperplasia of mammary glands was also diagnosed in 82.6 % of cases due to prolonged relative hyperestrogenism and hyperplastic diseases of the uterus and the ovaries, including genital endometriosis, endometrial hyperplasia, uterine myomas, were identified in 80.4 % of cases. A long-term monitoring (every 3 months) of thyroid-stimulating hormone, thyroglobulin, thyroglobulin antibodies, follicle-stimulating hormone, luteinizing hormone, prolactin, progesterone, free testosterone, estradiol levels and also the correction of cycle supply using hormonal and non-hormonal methods are needed for this category of patients.

Keywords


thyroidectomy; radioiodine therapy; relative hyperestrogenism; diffuse fibroadenomatosis of mammary glands; endometriosis; suppressive therapy with levothyroxine

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DOI: https://doi.org/10.22141/2224-0721.13.3.2017.104114

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