The characteristics of clinical, instrumental and hormonal parameters in patients with ACTH-dependent Cushing’s syndrome before and after the treatment

G.D. Narimova, Kh.R. Madaminova

Abstract


Background. Endogenous hypercorticoidism is characterized by a higher secretion of parathyroid hormone against the background of hypercalcemia. The purpose of the investigation was to study the characteristics of anthropometric, biochemical, hormonal, clinical and instrumental para­meters in patients with adrenocorticotropic hormone (ACTH) dependent Cushing’s syndrome before and 6 months after the treatment. Materials and methods. There were 60 patients with ACTH-dependent Cushing’s syndrome under supervision du­ring 2015–2016. Results. In the preoperative period in patients with ACTH-dependent Cushing’s syndrome, we have revealed significant deviations of both indicators of anthropometry and lipid metabolism (dyslipidemia). In the preoperative period in patients with ACTH-dependent Cushing’s syndrome, we have also detected significantly lower basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH) on the background of hypercortisolemia and hyperinsulinemia. Conclusions. Six months after selective transsphenoidal pituitary adenomectomy, group 1 patients were found to have significantly low values of mean levels of LH, FSH, GH, ACTH on the background of normal levels of cortisol and immunoreactive insulin, indicating postoperative hypopituitarism. In the postoperative period, patients with ACTH-dependent Cu­shing’s syndrome require hormone replacement therapy.


Keywords


ACTH-dependent Cushing’s syndrome; treatment

References


Kyryliuk ML. Diagnostics and treatment of pituitary Cushing’s syndrome. Mezhdunarodnyi Endokrinologicheskii Zhurnal. 2014;6:182-193. (In Russian).

Kalinin AP, Maystrenko NA, Vetshev PS. Hirurgicheskaja jendokrinologija. Rukovodstvo dlja vrachej [Surgical Endocrinology: Guidelines for physicians]. Saint-Petersburg: Piter; 2014. 960 p. (In Russian).

Abraham SB, Abel BS, Rubino D. A direct comparison of quality of life in obese and Cushing's syndrome patients. Eur J Endocrinol. 2013;168(5):787-93. doi: 10.1530/EJE-12-1078.

Badia X, Valassi E, Roset M. Disease-specific quality of life evaluation and its determinants in Cushing's syndrome: what have we learnt? Pituitary. 2014;17(2):187-95. doi: 10.1007/s11102-013-0484-2.

Keil MF. Quality of life and other outcomes in children treated for Cushing syndrome. J Clin Endocrinol Metab. 2013;98(7):2667-78. doi: 10.1210/jc.2013-1123.

Nelson LM, Forsythe A, McLeod L. Psychometric evaluation of the Cushing's Quality-of-Life questionnaire. Patient. 2013;6(2):113-24. doi: 10.1007/s40271-013-0012-5.

Neychev V, Steinberg SM, Yang L. Long-Term Outcome of Bilateral Laparoscopic Adrenalectomy Measured by Disease-Specific Questionnaire in a Unique Group of Patients with Cushing's Syndrome. Ann SurgOncol. 2015;22(3):699-706. doi: 10.1245/s10434-015-4605-1.

Crespo I, Valassi E, Santos A. Health-related quality of life in pituitary diseases. Endocrinol Metab Clin North Am. 2015;44(1):161-70. doi: 10.1016/j.ecl.2014.10.013.

Santos A, Crespo I, Aulinas A. Quality of life in Cushing's syndrome. Pituitary. 2015;18(2):195-200. doi: 10.1007/s11102-015-0640-y.

Tiemensma J, Depaoli S, Felt JM. Using subscales in the Cushing's quality of life questionnaire. Eur J Endocrinol. 2016;174(1):33-40. doi: 10.1530/EJE-15-0640.

Tritos NA, Biller BM, Swearingen B. Management of Cushing‘s syndrome. Nat Rev Endocrinol. 2011;7(5):279-89. doi: 10.1038/nrendo.2011.12.

Papoian V, Biller BM, Webb SM. Patients perception on clinical outcome and quality of life after a diagnosis of Cushing Syndrome. Endocr Pract. 2016;22(1):51-67. doi: 10.4158/EP15855.OR.

Roset M, Badia X, Forsythe A, Webb SM. Mapping Cushing QoL scores onto SF-6D utility values in patients with Cushing's syndrome. Patient. 2013;6(2):103-11. doi: 10.1007/s40271-013-0010-7.




DOI: https://doi.org/10.22141/2224-0721.13.3.2017.104113

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru