The incidence and features of subclinical Cushing’s syndrome in women with polycystic ovaries

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Yu.M. Urmanova
Z.Yu. Khalimova
G.D. Narimova
H.R. Madaminova
M.B. Abduvahabova
D.A. Alieva
D.Sh. Holova
H.O. Alimukhamedova
M.M. Karimova
F.S. Hodjaeva
H.K. Nasirova
N.T. Rihsieva


Background. The purpose of investigation is to study the incidence of subclinical Cushing’s syndrome in women with polycystic ovary syndrome (PCOS). Materials and methods. Under our supervision, there were 120 patients of fertile age with PCOS. The average age of patients was 25.5 ± 4.3 years. Twenty healthy women of corresponding age made a control group. The complex of researches, including clinical, biochemical, hormonal (luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, estradiol, progesterone, dehydroepiandrostendion, 17-hydroxyprogesterone, anti-Mullerian hormone, insulin on day 14 of cycle), was performed in all patients, as well as ultrasonography of the uterus and ovaries with folliculometry in dyna­mics, and also magnetic resonance imaging and survey of patients. Results. Patients were divided into three groups: with primary PCOS (19 %), with secondary PCOS and obesity (74 %), with secondary PCOS and subclinical Cushing’s syndrome (7 %).
In the first group of patients, a significant decrease of pituitary and ovarian hormones has been registered on the background of hyperandrogenemia. In the third group of patients, a signifi­cant decrease of pituitary hormones was also detected on the background of hyperandrogenemia. Conclusions. The most significant violations in the system of pituitary-ovarian function were found in the third group of patients with subclinical Cu­shing’s syndrome, at that, a significant decrease in the functional state of pituitary-gonadal system was marked, namely decline of LH, FSH, estradiol and progesterone on the background of hyperandrogenemia and hypercortisolemia. The incidence of subclinical Cushing’s syndrome among women with PCOS is 6.6 %. In future, it is necessary to monitor in dynamics the pro­bability of recovery of fertility in all groups of patients with PCOS

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Urmanova, Y., Z. Khalimova, G. Narimova, H. Madaminova, M. Abduvahabova, D. Alieva, D. Holova, H. Alimukhamedova, M. Karimova, F. Hodjaeva, H. Nasirova, and N. Rihsieva. “The Incidence and Features of Subclinical Cushing’s Syndrome in Women With Polycystic Ovaries”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 3, June 2017, pp. 157-61, doi:10.22141/2224-0721.13.3.2017.104112.
Original Researches


Findling JW, Raff H. Screening and diagnosis of Cushing’s syndrome. Endocrinol. Metab Clin North Am. 2005 Jun;34(2):385-402. doi: 10.1016/j.ecl.2005.02.001.

Nieman L. Cushing’s syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol. 2015; 73:33-8. doi: 10.1530/EJE-15-0464.

Chanson P, Salenave S. Metabolic syndrome in Cushing’s syndrome. Neuroendocrinology. 2010;92(suppl 1):96-101. doi: 10.1159/000314272.

Faggiano A, Pivonello R, Spiezia S, De Martino MC, et al. Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing’s disease during active disease and 1 year after disease remission. J Clin Endocrinol Metab. 2003;88:2527-33. doi: 10.1210/jc.2002-021558.

Giordano R. Metabolic and cardiovascular outcomes in patients with Cushing’s syndrome of different etiologies during active disease and 1 year after remission. Clin. Endocrinol. (Oxf). 2011 Sep;75(3):354-60. doi: 10.1111/j.1365-2265.2011.04055.x.

Chiodini I. Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case-control study in hospitalized patients. Eur J Endocrinol. 2005 Dec;153(6):837-44. doi: 10.1530/eje.1.02045.

Tiryakioglu O, Ugurlu S, Yalin S, Yirmibescik S, Caglar E, et al. Screening for Cushing’s syndrome in obese patients. Clinics (Sao Paulo). 2010;65(1):9-13. doi: 10.1590/S1807-59322010000100003.

Chiodini I, Mascia ML, Muscarella S, Battista C, Minisola S, Arosio M, Santini SA, et al. Subclinical hypercortisolism among outpatients referred for osteoporosis. Ann Intern Med. 2007 Oct 16;147(8):541-8. PMID: 17938392.

Zografos GN, Perysinakis I, Vassilatou E. Subclinical Cushing's syndrome: current concepts and trends. Hormones (Athens). 2014 Jul-Sep;13(3):323-37. PMID: 25079456.

Nieman LK, Biller BMK, Findling JW, et al. The Diagnosis of Cushing's syndrome: аn endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008 May;93(5):1526-40. doi: 10.1210%2Fjc.2008-0125.

Terzolo M, Pia A, Reimondo G. Subclinical Cushing’s syndrome: definition and management. Clinical Endocrinology. 2012 Jan;76(1):12-8. doi: 10.1111/j.1365-2265.2011.04253.x.

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