Influence of amorphous nanosilica on the parameters of multiparametric ultrasound investigation in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

P.M. Воdnar, N.A. Marunchyn, O.B. Dynnyk, E.P. Voronin, L.M Osynnia

Abstract


Background. The purpose of this study was to evaluate the influence of amorphous nanosilica on the indices of multiparametric ultrasound investigation in patients with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Materials and methods. The research was conducted in Kyiv endocrine centre in 2015–2017. Simultaneous abdominal ultrasound was made in all 105 patients on Soneus P7 device (Ultrasign, Ukraine) and included В-mode, dopplerography (-metry), strain and share wave elastography (-metry), steatography (-metry) with attenuation coefficient measurement to evaluate the effectiveness of treatment. We used amorphous nanosilica in suspension for the treatment of NAFLD. Results. There was found a decrease in the data of the right liver lobe elastography and its size, blood flow velocity of portal vein in the treatment group. Besides, there was also proved the reduction of progression of right lobe liver stiffness, size of the right and left liver lobes, the diameter and blood flow velocity of portal vein in the treatment group. Conclusions. The amorphous nanosilica can be recommended for the treatment of NAFLD in patients with T2DM, because it has hepatoprotective effect due to decrease in the data of right liver lobe elastography and its size, blood flow velocity of portal vein and the reduced progression of right lobe liver stiffness, size of right and left liver lobes, the diameter and blood flow velocity of portal vein.

Keywords


multiparametric ultrasound; nonalcoholic fatty liver disease; type 2 diabetes mellitus; amorphous nanosilica; sorbent

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DOI: https://doi.org/10.22141/2224-0721.13.3.2017.104111

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