Features of medical tactics and its perioperative medications in acute pancreatitis of biliary etiology in diabetic patients

S.I. Savoliuk, Y.V. Tomashevsky

Abstract


The aim of the study was clinical and laboratory evaluation of the effectiveness of traditional and optimized therapeutic and diagnostic technologies in acute pancreatitis of biliary etiology in diabetic patients with diabetes mellitus. Materials and methods. The article analyzes the results of treatment of 122 diabetic patients with acute biliary pancreatitis. Laboratory analysis was conducted within the monitoring cytopathic hypoxia markers, depending on the morphological forms of acute pancreatitis and effectiveness of optimized and traditional standard therapy. Results. The results indicate that acute pancreatitis of biliary etiology in diabetic patients was accompanied by a consistent pattern of imbalance in the cytopathic hypoxia system, which is determined by the severity of the pancreatic morphological changes. Interstitial form was accompanied by high levels of carbonyl group by 30.7 %, 38.75 % for adenosine deaminase and decreased level of arginine to 18.05 %; localized pancreatic necrosis was characterized by increased endothelial dysfunction markers (nitrates and nitrites to 18.35 %, homocysteine 52 %); diffuse pancreatic necrosis was characterized by increased markers of stimulated catabolism of purine nucleotides (xanthine and hypoxanthine to 85.2 %); subtotal-total pancreatic necrosis — increased levels of relative enzymes (xanthine oxidase and xanthine dehydrogenase) to 44.39 %. Pattern dynamics violations of cytopathic hypoxia markers allows use them as the predictors of functional liver failure and multiple organ failure in diabetic patients with necrotic forms of acute biliary pancreatitis. Conclusions. Standard treatment methods do not allow effectively correct cytopathic hypoxia, endotoxemia and hepatic failure. Proposed optimized complex of conservative therapy allow effectively and timely correction them, namely in the interstitial form on day 4, localized pancreatic necrosis on day 7, diffuse pancreatic necrosis on day 10, subtotal-total form on the 14th day after the medical treatment started. Supplementation of standard treatment regimens for the edematic form of acute pancreatitis with a systemic multifunctional metabolic corrector allow impact the homeostatic disorders caused by enzyme toxemia, in particular metabolic and ischemic-reperfusion mechanisms of hepatic dysfunction formation that, under the condition of destructive forms, requires additional drugs of low molecular weight heparins for the recovery of hemorheological features at at the systemic and intraorgan levels.


Keywords


гострий панкреатит біліарної етіології; цукровий діабет; цитопатична гіпоксія; печінкова дисфункція; ендотоксикоз; методи ендоскопічної щадної біліарної декомпресії

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DOI: https://doi.org/10.22141/2224-0721.13.2.2017.100606

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