Evaluating the quality of life of patients with Cushing’s syndrome in surgical and conservative treatment

Main Article Content

G.D. Narimova
Kh.R. Madaminova


Research aim — to study the quality of life of patients with Cushing’s syndrome (CS) depending on the disease duration and applied methods of treatment. Materials and methods. The features of quality of life were studied in 60 patients with CS applied for infertility. The average age of patients was 33.9 ± 12.5 years. The duration of disease was from 3 months to 5 years. The spectrum of researches included clinical, biochemical studies, radioimmune hormonal methods of analysis of the blood, ultrasonic densitometry, which were used in all patients. In all patients, we performed magnetic resonance imaging of the pituitary gland and computed tomography of adrenals. An oral glucose tolerance test was used, if necessary. To evaluate the quality of life of patients, the short version of health questionnaire was used (MOS 36-Item Short-Form Health Survey — MOS SF-36). 36 points of questionnaire were grouped in eight scales. Indexes of every scale vary between 0 and 100, where 100 presents the complete health. Results. Before the treatment, women with СS in the subgroup with complications reported the reliable increase of basal values of adrenocorticotropic hormone (ACTH), cortisol, prolactin on the background of hyperandrogenemia and ovarian insufficiency. In patients with СS from the second subgroup (without complications), against the background of significant increase of basal values of cortisol, prolactin, hyperandrogenemia, there was marked unreliable decline of estradiol and progesterone levels. In patients with СS with surgical treatment in the subgroup with complications, 1 month after the surgery the normalization of levels of ACTH and cortisol was marked, and through 6 months this state was saved. In patients with СS with surgical treatment in subgroup 2 (without complications) 1 month after the operation, the normalization of levels of ACTH and cortisol was marked, and through 6 months the state remained former. Conclusions. Six months after the conducted conservative therapy for patients with CS, in 21 (81 %) of them hypercorticoidism was saved, and the parameters of quality of life remained lower than in the group of patients with surgical treatment and healthy people.

Article Details

How to Cite
Narimova, G., and K. Madaminova. “Evaluating the Quality of Life of Patients With Cushing’s Syndrome in Surgical and Conservative Treatment”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 2, May 2017, pp. 140-6, doi:10.22141/2224-0721.13.2.2017.100603.
Original Researches


Abraham SB, Abel BS, Rubino D. A direct comparison of quality of life in obese and Cushing's syndrome patients. Eur J Endocrinol. 2013;168(5):787-93. doi: 10.1530/EJE-12-1078.

Badia X, Valassi E, Roset M Disease-specific quality of life evaluation and its determinants in Cushing's syndrome: what have we learnt? Pituitary. 2014;17(2):187-95. doi: 10.1007/s11102-013-0484-2.

Keil MF. Quality of life and other outcomes in children treated for Cushing syndrome. J Clin Endocrinol Metab. 2013;98(7):2667-78. doi: 10.1210/jc.2013-1123.

Nelson LM, Forsythe A, McLeod L. Psychometric evaluation of the Cushing's Quality-of-Life questionnaire. Patient. 2013;6(2):113-24. doi: 10.1007/s40271-013-0012-5.

Neychev V, Steinberg SM, Yang L, et al. Long-Term Outcome of Bilateral Laparoscopic Adrenalectomy Measured by Disease-Specific Questionnaire in a Unique Group of Patients with Cushing's Syndrome. Ann Surg Oncol. 2015;22(3):699-706. doi: 10.1245/s10434-015-4605-1.

Crespo I, Valassi E, Santos A. Health-related quality of life in pituitary diseases. Endocrinol Metab Clin North Am. 2015;44(1):161-70. doi: 10.1016/j.ecl.2014.10.013.

Santos A, Crespo I, Aulinas A. Quality of life in Cushing's syndrome. Pituitary. 2015 Apr;18(2):195-200. doi: 10.1007/s11102-015-0640-y.

Tiemensma J, Depaoli S, Felt JM. Using subscales when scoring the Cushing's quality of life questionnaire. Eur J Endocrinol. 2016;174(1):33-40. doi: 10.1530/EJE-15-0640.

Tritos NA, Biller BM, Swearingen B. Management of Cushing’s syndrome. Nat Rev Endocrinol. 2011;7:279-289. PMID: 21301487. doi: 10.1038/nrendo.2011.12.

Papoian V, Biller BM, Webb SM. Patients’ perception on clinical outcome and quality of life after a diagnosis of Cushing Syndrome. Endocr Pract. 2016 Jan;22(1):51-67. PMID: 26437213. doi: 10.4158/EP15855.OR.

Roset M, Badia X, Forsythe A. Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome. Patient. 2013;6(2):103-11. doi: 10.1007/s40271-013-0010-7.